{"id":"W4409126994","doi":"10.1186/s12931-025-03194-w","title":"MARCKS protein is a potential target in a naturally occurring equine model of neutrophilic asthma","year":2025,"lang":"en","type":"article","venue":"Respiratory Research","topic":"Protein Kinase Regulation and GTPase Signaling","field":"Biochemistry, Genetics and Molecular Biology","cited_by":2,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Montréal; Cegep de Saint Hyacinthe","funders":"National Institutes of Health; National Institute of Allergy and Infectious Diseases; North Carolina State University; Morris Animal Foundation","keywords":"Asthma; Immunology; MARCKS; Medicine; Biology; Signal transduction; Cell biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000295165,0.000423989,0.0004535771,0.0002441066,0.0002676134,0.0003261449,0.0003235213,0.0005645012,0.001181246],"category_scores_gemma":[0.0001953224,0.00009835999,0.0002573051,0.0001261226,0.0003535475,0.0002527295,0.0001605322,0.0008963797,0.0003731343],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004025961,"about_ca_system_score_gemma":0.0002884131,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003023487,"about_ca_topic_score_gemma":0.0006337282,"domain_scores_codex":[0.9997641,0.00004895852,0.0000258071,0.00004099628,0.00006121678,0.0000587903],"domain_scores_gemma":[0.999861,0.00001821219,0.0000410768,0.00001360486,0.00002377642,0.00004237777],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0008003649,0.0003088514,0.0003447346,0.0001488314,0.000009766423,0.0001120075,0.00002595495,0.0001097051,0.9960395,0.00007473041,0.0001021909,0.001923255],"study_design_scores_gemma":[0.0001986601,0.009486167,0.00826887,0.00003518954,0.00007035014,0.001418645,0.00008405928,0.001569546,0.9705219,0.0000862688,0.008247366,0.00001304603],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9935002,0.003208751,0.001627418,0.0002965828,0.00009178843,0.0001286201,0.0002876043,0.00006746833,0.0007915613],"genre_scores_gemma":[0.9919471,0.001668255,0.00296012,0.0001088607,0.00003920397,0.0002415184,0.0008645304,0.000008388239,0.002161984],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001181246,"threshold_uncertainty_score":0.003951669,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0406953740049853,"score_gpt":0.3512628046165693,"score_spread":0.310567430611584,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}