{"id":"W4409141019","doi":"10.1021/acsptsci.5c00126","title":"Synthesis, Characterization, Interactions, and Immunomodulatory Function of Ectonucleotidase CD39/CD73 Inhibitor 8-Butylthioadenosine 5′-Monophosphate","year":2025,"lang":"en","type":"article","venue":"ACS Pharmacology & Translational Science","topic":"Adenosine and Purinergic Signaling","field":"Biochemistry, Genetics and Molecular Biology","cited_by":5,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université Laval; Centre hospitalier de l'Université Laval","funders":"Fonds de recherche du Québec; Deutsche Forschungsgemeinschaft; Natural Sciences and Engineering Research Council of Canada; Government of Canada","keywords":"Chemistry; Function (biology); Adenosine monophosphate; Pharmacology; Biochemistry; Cell biology; Adenosine; Biology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001088746,0.0002641756,0.0001779895,0.0001863547,0.0001301346,0.0001496451,0.0002080126,0.0001992424,0.0007620589],"category_scores_gemma":[0.0001435774,0.00007488357,0.0001581301,0.0002466302,0.00007662599,0.0001534879,0.00009954883,0.0003204852,0.0003269865],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001911477,"about_ca_system_score_gemma":0.0001735213,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004026622,"about_ca_topic_score_gemma":0.0005783224,"domain_scores_codex":[0.9999136,0.00001164235,0.000006557157,0.00001408574,0.00003657187,0.00001758379],"domain_scores_gemma":[0.9999533,0.000005124079,0.00001395765,0.0000045287,0.000009765912,0.00001330697],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0000973873,0.00008467984,0.0001335953,0.00009473812,0.000007535492,0.0001160942,0.00001179382,0.0004860044,0.9905433,0.0001797837,0.0001795023,0.008065641],"study_design_scores_gemma":[0.00002595901,0.0004941295,0.0007340431,0.000006432933,0.00002009495,0.0002407765,0.000007094606,0.001103597,0.9898822,0.00004148412,0.007437328,0.000006914936],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9670509,0.01333584,0.01232921,0.0002224249,0.00005013798,0.0001819092,0.001120328,0.00009846637,0.005610856],"genre_scores_gemma":[0.980915,0.005095023,0.008936443,0.00008887775,0.00002599215,0.00009105835,0.001310503,0.00002543133,0.003511806],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0007620589,"threshold_uncertainty_score":0.002549291,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.00587930248545084,"score_gpt":0.2657652468192829,"score_spread":0.2598859443338321,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}