{"id":"W4409147776","doi":"10.1080/07366205.2025.2484094","title":"A drug screening platform for protein expression levels in neurological disorders","year":2025,"lang":"en","type":"article","venue":"BioTechniques","topic":"Lysosomal Storage Disorders Research","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; McGill University Health Centre","funders":"Canadian Institutes of Health Research; Québec Consortium for Drug Discovery; Weston Brain Institute","keywords":"Biology; Gene; Gene expression; Protein expression; Population; Drug; Drug discovery; Computational biology; Cas9; Target protein; Reporter gene; CRISPR; Molecular biology; Genetics; Bioinformatics; Pharmacology; Medicine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0008521959,0.0009697191,0.001062995,0.001181276,0.000412487,0.0007411219,0.0006361136,0.0009586014,0.003713433],"category_scores_gemma":[0.000708256,0.0004229893,0.0006312269,0.0005135321,0.0003421225,0.0004383687,0.0007728239,0.0009186136,0.001949576],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004958355,"about_ca_system_score_gemma":0.0005341435,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004632733,"about_ca_topic_score_gemma":0.0006700545,"domain_scores_codex":[0.9990804,0.0001281712,0.00005643199,0.0002264736,0.0004317165,0.00007677078],"domain_scores_gemma":[0.9994556,0.0001751368,0.0001024201,0.00007023414,0.0001247703,0.00007175585],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001568226,0.0001130557,0.0002888937,0.00007710672,0.00002569931,0.0001077433,0.00002021746,0.0004961184,0.9863889,0.0003596174,0.0009227097,0.01104308],"study_design_scores_gemma":[0.00005401372,0.0006624552,0.00145846,0.00001185739,0.00004721379,0.0003563171,0.00001024705,0.005167166,0.9843749,0.000205882,0.007621268,0.00003020962],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.4800816,0.004227226,0.4611509,0.001567501,0.0004140588,0.002239908,0.01357654,0.02366169,0.01308052],"genre_scores_gemma":[0.6782548,0.003541076,0.2806115,0.001057136,0.00009470345,0.003082313,0.01044664,0.0007112242,0.02220056],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003713433,"threshold_uncertainty_score":0.01242268,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04254518870028336,"score_gpt":0.3480692550993486,"score_spread":0.3055240663990652,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}