{"id":"W4409148563","doi":"10.1128/aac.01867-24","title":"Activity of novel ceftibuten-avibactam, ceftazidime-avibactam, and comparators against a challenge set of <i>Enterobacterales</i> from outpatient centers and nursing homes across the United States (2022–2024)","year":2025,"lang":"en","type":"article","venue":"Antimicrobial Agents and Chemotherapy","topic":"Antibiotic Resistance in Bacteria","field":"Biochemistry, Genetics and Molecular Biology","cited_by":3,"is_retracted":false,"has_abstract":true,"ca_institutions":"Quest University Canada","funders":"Pfizer","keywords":"Avibactam; Medicine; Ertapenem; Ceftazidime/avibactam; Cefpodoxime; Carbapenem; Trimethoprim; Pharmacology; Ceftriaxone; Meropenem; Microbiology; Chemistry; Antibiotics; Klebsiella pneumoniae; Biology; Antibiotic resistance","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0006173016,0.0003259985,0.0004821557,0.0002474982,0.000177347,0.00036556,0.000334577,0.000515499,0.00155088],"category_scores_gemma":[0.0008981854,0.0001489907,0.000307807,0.0002766174,0.0001468643,0.0002898537,0.0002103092,0.0003799602,0.000213277],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003780309,"about_ca_system_score_gemma":0.0003428021,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001928719,"about_ca_topic_score_gemma":0.003619809,"domain_scores_codex":[0.9996827,0.0001183485,0.00004135844,0.00006029935,0.00006192275,0.00003532966],"domain_scores_gemma":[0.999632,0.00008942006,0.00007002341,0.00002149438,0.00009439787,0.00009258767],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.1086161,0.01621849,0.05738775,0.0009921639,0.0007461168,0.0006889665,0.0003914196,0.00304358,0.7288381,0.0002188568,0.002195462,0.08066305],"study_design_scores_gemma":[0.01266456,0.3865907,0.1875711,0.00016164,0.0008400166,0.002768011,0.0005096946,0.00717088,0.3906942,0.0001454046,0.01081578,0.00006801491],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9985827,0.0005813324,0.00009372802,0.00003348515,0.00002006523,0.00005109423,0.0002676656,0.00001005739,0.0003598277],"genre_scores_gemma":[0.9975643,0.0002768418,0.0005817445,0.00004546921,0.00001718052,0.00003610248,0.001078249,0.000004025919,0.0003960964],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001928719,"threshold_uncertainty_score":0.005188227,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01195127095486655,"score_gpt":0.2733669312672306,"score_spread":0.2614156603123641,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}