{"id":"W4409149543","doi":"10.1101/2025.03.25.645315","title":"Myelin antigen-specific effector CD8 <sup>+</sup> T cells induce chronic CNS autoimmunity in a CD4 <sup>+</sup> T cell-dependent manner","year":2025,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"Neuroinflammation and Neurodegeneration Mechanisms","field":"Neuroscience","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université Laval; Centre hospitalier de l'Université Laval","funders":"Canadian Institutes of Health Research; Multiple Sclerosis Society; Multiple Sclerosis Society of Canada","keywords":"Autoimmunity; Effector; Myelin; Cytotoxic T cell; Immunology; Antigen; T cell; CD8; Biology; Molecular biology; Cell biology; Central nervous system; Neuroscience; Immune system; Genetics; In vitro","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002619307,0.0006198239,0.0002934531,0.0004103323,0.0001660258,0.0003515649,0.0002019256,0.000316714,0.001969263],"category_scores_gemma":[0.000107118,0.0001928594,0.0002511135,0.000148479,0.0003093056,0.0002043062,0.0001996893,0.00112506,0.0006986347],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002110901,"about_ca_system_score_gemma":0.0001712045,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002637845,"about_ca_topic_score_gemma":0.0005194529,"domain_scores_codex":[0.9996793,0.00005050102,0.00005292058,0.00004692235,0.00006747995,0.000102891],"domain_scores_gemma":[0.9997228,0.00004328074,0.00007005963,0.00004018646,0.00003110725,0.00009254683],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002556419,0.0001435179,0.0002531231,0.00004936293,0.000004437147,0.00007551444,0.00001424206,0.0000438267,0.9984083,0.00002812671,0.0000492833,0.0006748049],"study_design_scores_gemma":[0.000126778,0.002677488,0.009376811,0.00002933016,0.00003091817,0.0008456515,0.00006903524,0.001194421,0.9834419,0.00006233538,0.002138834,0.000006505253],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9971335,0.0006267899,0.0007642957,0.00006318116,0.00002859266,0.00004313889,0.0003075015,0.00008814697,0.000944718],"genre_scores_gemma":[0.9920682,0.0005101241,0.001590912,0.0001217154,0.00004774305,0.0001092645,0.0008188973,0.00003474259,0.004698396],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001969263,"threshold_uncertainty_score":0.006587863,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02167167007765267,"score_gpt":0.2294900748608913,"score_spread":0.2078184047832386,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}