{"id":"W4409150081","doi":"10.1016/s2468-1253(24)00439-4","title":"Prevention and interception trials in inflammatory bowel disease: an international taskforce assessment on clinical trial design","year":2025,"lang":"en","type":"review","venue":"˜The œLancet. Gastroenterology & hepatology","topic":"Inflammatory Bowel Disease","field":"Biochemistry, Genetics and Molecular Biology","cited_by":12,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Toronto; Western University; Mount Sinai Hospital","funders":"National Institute of Diabetes and Digestive and Kidney Diseases; Hospital for Sick Children; Celltrion; Genentech; Celgene; Pfizer; Bristol-Myers Squibb; Eli Lilly and Company; Biogen","keywords":"Medicine; Inflammatory bowel disease; Clinical trial; Interception; Intensive care medicine; Disease; Internal medicine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.07568154,0.001132776,0.006546223,0.001475222,0.0003662308,0.002777746,0.002885366,0.00373277,0.003424122],"category_scores_gemma":[0.07577094,0.000603869,0.003462165,0.001934199,0.001071142,0.001676882,0.001850897,0.004647946,0.001085337],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00275747,"about_ca_system_score_gemma":0.007187368,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002127193,"about_ca_topic_score_gemma":0.003364239,"domain_scores_codex":[0.9742897,0.0187719,0.002259058,0.0007570091,0.003450632,0.0004717464],"domain_scores_gemma":[0.8901633,0.09594405,0.005577787,0.001611815,0.005695599,0.001007561],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"theoretical_or_conceptual","study_design_scores_codex":[0.003615895,0.00008705301,0.0004086684,0.07278299,0.003666191,0.00005164661,0.0001200796,0.0005588403,0.0004170988,0.01039861,0.05728919,0.8506038],"study_design_scores_gemma":[0.01803797,0.002179112,0.005864989,0.258222,0.01975646,0.0005043418,0.0001842501,0.001206859,0.0008664941,0.02669499,0.6663363,0.0001462461],"study_design_candidate":"theoretical_or_conceptual","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.00024747,0.9908934,0.0007805352,0.00536266,0.001172178,0.0003209618,0.0001688307,0.00002434129,0.00102964],"genre_scores_gemma":[0.006046231,0.9787361,0.004945119,0.006265051,0.001258676,0.001617884,0.0003240997,0.00002510066,0.0007816555],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.07568154,"threshold_uncertainty_score":0.400247,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.09968612847635465,"score_gpt":0.4330034619466804,"score_spread":0.3333173334703258,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}