{"id":"W4409151142","doi":"10.1038/s41537-025-00556-7","title":"Sample ascertainment and clinical outcome measures in the Accelerating Medicines Partnership® Schizophrenia Program","year":2025,"lang":"en","type":"article","venue":"Schizophrenia","topic":"Schizophrenia research and treatment","field":"Medicine","cited_by":9,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; Douglas College; Hotchkiss Brain Institute; École de Technologie Supérieure; University of Calgary","funders":"National Institute of Mental Health; U.S. Department of Health and Human Services","keywords":"Schizophrenia (object-oriented programming); Sample (material); Outcome (game theory); General partnership; Sampling bias; Medicine; Psychiatry; Psychology; Clinical psychology; Sample size determination; Statistics; Business; Economics; Mathematics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.002289985,0.0004366055,0.0008173213,0.0003881587,0.0003190637,0.0001980081,0.0003845803,0.0002263034,0.00006877528],"category_scores_gemma":[0.00293013,0.0002652678,0.0002596763,0.0008799739,0.0004234193,0.0001236064,0.0001417763,0.001047831,0.00002957725],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001302025,"about_ca_system_score_gemma":0.0004818838,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002407443,"about_ca_topic_score_gemma":0.001962206,"domain_scores_codex":[0.9959173,0.0005435842,0.001096174,0.0007788474,0.0009006358,0.0007634757],"domain_scores_gemma":[0.9970799,0.001417417,0.0001783517,0.0008390767,0.0001391856,0.0003460772],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0117535,0.001018473,0.6309554,0.00012587,0.0003266888,0.0002201186,0.0001742253,0.000001646525,0.00002901433,0.009587724,0.001638693,0.3441687],"study_design_scores_gemma":[0.0180518,0.0009758141,0.9694117,0.000337409,0.0003426264,0.00006269656,0.0007178418,0.000670413,0.00008180858,0.004748893,0.00432054,0.0002784945],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9764417,0.002266109,0.00006509433,0.01612268,0.0002518238,0.002542628,0.0000115056,0.0001950279,0.002103477],"genre_scores_gemma":[0.9820285,0.0002076786,0.01473648,0.001830145,0.0004017462,0.0005259669,0.00004996817,0.00003135141,0.0001881769],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.3438902,"threshold_uncertainty_score":0.99998,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.09430584189841953,"score_gpt":0.4203122324248825,"score_spread":0.326006390526463,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}