{"id":"W4409151969","doi":"10.1093/biolre/ioaf079","title":"Double knockout of steroidogenic factor 1 (<i>NR5A1</i>) and liver receptor homolog 1 (<i>NR5A2</i>) in the mouse ovary results in infertility due to disruption of follicle development and ovulation","year":2025,"lang":"en","type":"article","venue":"Biology of Reproduction","topic":"Reproductive System and Pregnancy","field":"Immunology and Microbiology","cited_by":2,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Sherbrooke; Université de Montréal; Cegep de Saint Hyacinthe","funders":"","keywords":"Biology; Endocrinology; Internal medicine; Liver receptor homolog-1; Ovary; Steroidogenic factor 1; Conditional gene knockout; Follicular phase; Nuclear receptor; Ovulation; Ovarian follicle; Hormone; Transcription factor; Phenotype; Genetics; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003251031,0.0008779588,0.0004805961,0.001154172,0.0003913963,0.0006115009,0.0006575625,0.0008848669,0.004535406],"category_scores_gemma":[0.0001608446,0.0006128036,0.0007472268,0.0003324397,0.000883622,0.0004374274,0.0006580054,0.001129534,0.001327442],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004473474,"about_ca_system_score_gemma":0.0003459659,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009264735,"about_ca_topic_score_gemma":0.002328457,"domain_scores_codex":[0.9991881,0.00006245261,0.0001164363,0.0002702473,0.0002156676,0.0001469825],"domain_scores_gemma":[0.9994153,0.00003804351,0.000251194,0.00005107649,0.00002644476,0.0002180075],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001137013,0.00002894061,0.0002542984,0.00003974377,0.00001111898,0.00012814,0.00002714164,0.0000308062,0.9981661,0.0002923807,0.00007253949,0.0008351051],"study_design_scores_gemma":[0.0001053189,0.0003968687,0.009644716,0.00003141693,0.00006765495,0.001435119,0.00008897589,0.0007960341,0.9782031,0.0001252298,0.00908241,0.00002325266],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9765682,0.001942411,0.01280676,0.000299869,0.0001926674,0.0001357595,0.003012313,0.0007143638,0.004327634],"genre_scores_gemma":[0.9539782,0.00140346,0.01395205,0.0002948393,0.00005104494,0.0003205928,0.002536265,0.000382315,0.02708109],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004535406,"threshold_uncertainty_score":0.01517242,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0263797131991639,"score_gpt":0.2711543588891175,"score_spread":0.2447746456899536,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}