{"id":"W4409151969","doi":"10.1093/biolre/ioaf079","title":"Double knockout of steroidogenic factor 1 (<i>NR5A1</i>) and liver receptor homolog 1 (<i>NR5A2</i>) in the mouse ovary results in infertility due to disruption of follicle development and ovulation","year":2025,"lang":"en","type":"article","venue":"Biology of Reproduction","topic":"Reproductive System and Pregnancy","field":"Immunology and Microbiology","cited_by":2,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Sherbrooke; Université de Montréal; Cegep de Saint Hyacinthe","funders":"","keywords":"Biology; Endocrinology; Internal medicine; Liver receptor homolog-1; Ovary; Steroidogenic factor 1; Conditional gene knockout; Follicular phase; Nuclear receptor; Ovulation; Ovarian follicle; Hormone; Transcription factor; Phenotype; Genetics; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001254954,0.0001274057,0.0003692298,0.0002575194,0.00004502218,0.000002366746,0.0001022626,0.0002091265,0.000007830611],"category_scores_gemma":[0.0002721841,0.00009884076,0.00003179664,0.0003047188,0.0002348455,0.00008676283,0.00008503022,0.0001245828,0.000002564897],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003254437,"about_ca_system_score_gemma":0.00004774129,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006027148,"about_ca_topic_score_gemma":0.0003415687,"domain_scores_codex":[0.998071,0.0004947656,0.000689811,0.0005651384,0.0000293274,0.0001499305],"domain_scores_gemma":[0.9990584,0.0001073927,0.0002606865,0.0004501066,0.0001151283,0.000008326635],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.001578182,0.0002232817,0.2206644,0.0001990064,0.00007117155,4.092255e-7,0.006541626,0.00001009583,0.7272372,0.0002830732,0.0000750728,0.04311647],"study_design_scores_gemma":[0.00100873,0.0001484999,0.5639671,0.00006935248,0.000007645623,0.000009908466,0.0002368959,3.674285e-7,0.4330331,0.0001157738,0.00134221,0.00006037858],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9823092,0.01606622,0.0001340843,0.0003472691,0.0002884154,0.000748445,0.00003523854,0.00001004268,0.00006110687],"genre_scores_gemma":[0.9990277,0.0002008401,0.0003689046,0.000008219095,0.00001374297,0.00004251273,0.00006357019,0.000004178287,0.0002703634],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.3433027,"threshold_uncertainty_score":0.4030609,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0263797131991639,"score_gpt":0.2711543588891175,"score_spread":0.2447746456899536,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}