{"id":"W4409159437","doi":"10.1089/ipm.12.02.03","title":"Knocking Down Barriers to Precision Oncology with Companion Diagnostics","year":2025,"lang":"en","type":"article","venue":"Inside Precision Medicine","topic":"Cancer Genomics and Diagnostics","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":false,"ca_institutions":"Optech (Canada)","funders":"","keywords":"Precision oncology; Medical physics; Medicine; Internal medicine; Oncology; Cancer","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.006816716,0.0007981312,0.001359093,0.0009411662,0.0010608,0.005667968,0.001632933,0.003506023,0.01445015],"category_scores_gemma":[0.01631399,0.0006628114,0.0008650108,0.0005933176,0.00464979,0.008574883,0.005328767,0.009727162,0.00459587],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00205338,"about_ca_system_score_gemma":0.002383972,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005925665,"about_ca_topic_score_gemma":0.0005696779,"domain_scores_codex":[0.9958477,0.001281313,0.0001664934,0.0005283137,0.001626728,0.0005494442],"domain_scores_gemma":[0.9882287,0.006709442,0.001108201,0.001511249,0.00137392,0.001068448],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"theoretical_or_conceptual","study_design_gemma":"not_applicable","study_design_scores_codex":[0.000763565,0.0003777033,0.003016612,0.002049567,0.0002453032,0.0006094424,0.0009302339,0.002963126,0.06796188,0.6164462,0.07218645,0.2324499],"study_design_scores_gemma":[0.0001256268,0.0007486633,0.001726306,0.0009654081,0.0001237904,0.001390575,0.0006343295,0.00365609,0.03813329,0.3678912,0.5845142,0.00009050264],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"commentary","genre_gemma":"commentary","genre_scores_codex":[0.07200075,0.2730159,0.2359776,0.2825739,0.01184126,0.0003034578,0.001332754,0.00330708,0.1196474],"genre_scores_gemma":[0.7097012,0.1065912,0.08408012,0.05568722,0.00887436,0.0005513336,0.001018272,0.0009387619,0.03255752],"genre_candidate":"commentary","genre_consensus":"commentary","teacher_disagreement_score":0.01445015,"threshold_uncertainty_score":0.04834062,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01103564715734878,"score_gpt":0.3014312318579663,"score_spread":0.2903955847006175,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}