{"id":"W4409168872","doi":"10.1101/2025.04.03.647108","title":"Gangliosides Modulate the Secretion of Extracellular Vesicles and Their Misfolded Protein Cargo","year":2025,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"Glycosylation and Glycoproteins Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Alberta Glycomics Centre; Women and Children’s Health Research Institute; University of Alberta","funders":"","keywords":"Secretion; Cell biology; Extracellular vesicles; Extracellular; Vesicle; Chemistry; Secretory pathway; Transport protein; Secretory protein; Biochemistry; Biology; Golgi apparatus; Membrane; Endoplasmic reticulum","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001345649,0.0002569714,0.0001841333,0.0001503457,0.00008763602,0.0003030277,0.00008147915,0.0001915723,0.00101285],"category_scores_gemma":[0.00006223545,0.00006224227,0.0001530832,0.0001095895,0.0001453279,0.0001776121,0.0002271137,0.0002170644,0.0003699855],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002445077,"about_ca_system_score_gemma":0.000120162,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000371171,"about_ca_topic_score_gemma":0.0002826834,"domain_scores_codex":[0.9999416,0.00001072191,0.000004251925,0.00001035017,0.00001760692,0.00001535254],"domain_scores_gemma":[0.9999685,0.000006600722,0.000007422489,0.000003955694,0.000005189363,0.00000821901],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0000762918,0.000005690079,0.000139183,0.00002335038,0.000003118197,0.00004225672,0.000008607614,0.00006753055,0.9987016,0.0001369533,0.00003636512,0.0007590188],"study_design_scores_gemma":[0.00001024688,0.00005328544,0.001763703,0.000003873101,0.00000631676,0.00006608765,0.00001519626,0.0005744021,0.9957123,0.0001301586,0.001662632,0.000001844363],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9923556,0.002423143,0.002441057,0.0001306427,0.00005102949,0.00001819589,0.0003723101,0.00006047564,0.002147561],"genre_scores_gemma":[0.9895847,0.00155095,0.002386944,0.0000662139,0.00002022887,0.00001480162,0.0004024621,0.00003805624,0.005935504],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00101285,"threshold_uncertainty_score":0.003388345,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0112325389573196,"score_gpt":0.2241654577872718,"score_spread":0.2129329188299522,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}