{"id":"W4409172307","doi":"10.1016/j.stem.2025.02.014","title":"A robust ingredient makes human gut stem cell niches on a dish","year":2025,"lang":"en","type":"article","venue":"Cell stem cell","topic":"Cancer Cells and Metastasis","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":false,"ca_institutions":"SickKids Foundation; Hospital for Sick Children; University of Toronto","funders":"Canadian Institutes of Health Research","keywords":"Biology; Stem cell; Niche; Ingredient; Stem cell niche; Ecological niche; Cell biology; Ecology; Food science; Progenitor cell; Habitat","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.000282331,0.0004278734,0.0006723596,0.0002643547,0.0002249292,0.00008122469,0.0002698835,0.0001852521,0.0003241586],"category_scores_gemma":[0.0000022857,0.0003751021,0.0003397168,0.0004330699,0.00009095011,0.00005465112,0.0001577552,0.0004267696,0.0002578321],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003082615,"about_ca_system_score_gemma":0.0001892212,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001288877,"about_ca_topic_score_gemma":0.00006765674,"domain_scores_codex":[0.9975051,0.00008234284,0.0005722582,0.0007775918,0.0004363441,0.0006263636],"domain_scores_gemma":[0.9984095,0.0001078184,0.0002035092,0.0008773765,0.0001081333,0.0002936513],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001475533,0.00731827,0.01209761,0.01455309,0.0004027004,0.0008510301,0.006263589,0.001180203,0.4887219,0.0007692003,0.3839895,0.08237739],"study_design_scores_gemma":[0.004737187,0.0008658904,0.001206287,0.0006362598,0.0006285392,0.000006229181,0.003224458,0.0001164594,0.5753839,0.00002816104,0.4126055,0.0005610829],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.6337224,0.004818301,0.0001679935,0.0003130786,0.0009920725,0.0008538218,0.00003763283,0.0001496614,0.358945],"genre_scores_gemma":[0.805878,0.0003050697,0.0001664857,0.0007837206,0.0002177347,0.00006572541,0.00003185794,0.00005625175,0.1924952],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1721556,"threshold_uncertainty_score":0.9998701,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03478027729564823,"score_gpt":0.2571162364368415,"score_spread":0.2223359591411933,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}