{"id":"W4409172307","doi":"10.1016/j.stem.2025.02.014","title":"A robust ingredient makes human gut stem cell niches on a dish","year":2025,"lang":"en","type":"article","venue":"Cell stem cell","topic":"Cancer Cells and Metastasis","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":false,"ca_institutions":"SickKids Foundation; Hospital for Sick Children; University of Toronto","funders":"Canadian Institutes of Health Research","keywords":"Biology; Stem cell; Niche; Ingredient; Stem cell niche; Ecological niche; Cell biology; Ecology; Food science; Progenitor cell; Habitat","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005693112,0.0007949652,0.0004230251,0.0005950085,0.0004001315,0.000729577,0.0005678099,0.0009902257,0.005171258],"category_scores_gemma":[0.0005078974,0.0004810968,0.000644059,0.0002794645,0.0005527117,0.0005476513,0.001201788,0.001524389,0.003011932],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000270935,"about_ca_system_score_gemma":0.0003366672,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003859366,"about_ca_topic_score_gemma":0.001202708,"domain_scores_codex":[0.9994133,0.00006269096,0.00005138751,0.0001456315,0.0002502628,0.00007683482],"domain_scores_gemma":[0.9994745,0.0001099033,0.0001055096,0.0001194615,0.00005536871,0.0001352013],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00005879916,0.00002975562,0.0001470218,0.00006314417,0.000008225415,0.0001109594,0.00003534171,0.000121667,0.9955379,0.0004665201,0.0004172655,0.003003547],"study_design_scores_gemma":[0.00003531715,0.0003587261,0.001748968,0.00003094998,0.00005288703,0.0003914809,0.0001088254,0.0009203935,0.9648845,0.0003040708,0.03114434,0.00001964912],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.848364,0.005662754,0.07985753,0.0038099,0.002579684,0.0005347868,0.004654149,0.002655106,0.05188209],"genre_scores_gemma":[0.8339103,0.002368869,0.1212354,0.001096308,0.0003650371,0.000340957,0.003767391,0.0009336826,0.03598195],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.005171258,"threshold_uncertainty_score":0.01729959,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03478027729564823,"score_gpt":0.2571162364368415,"score_spread":0.2223359591411933,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}