{"id":"W4409175552","doi":"10.1111/apt.70132","title":"Letter: Lubiprostone Treatment for <scp>MASLD</scp>—Gender Imbalance and Blinding Considerations. Authors' Reply","year":2025,"lang":"en","type":"letter","venue":"Alimentary Pharmacology & Therapeutics","topic":"Genetic factors in colorectal cancer","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Calgary","funders":"","keywords":"Lubiprostone; Blinding; Medicine; Food science; Internal medicine; Clinical trial; Chemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.006844358,0.0007484711,0.001640311,0.0007300541,0.001680955,0.001862718,0.002243434,0.02554071,0.004964129],"category_scores_gemma":[0.05766868,0.0005109902,0.001341693,0.0005412091,0.002381009,0.003017018,0.001074031,0.02015667,0.003505767],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.002533403,"about_ca_system_score_gemma":0.002629825,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001892613,"about_ca_topic_score_gemma":0.00155244,"domain_scores_codex":[0.9955404,0.002010553,0.0008407818,0.000533458,0.0007933071,0.000281389],"domain_scores_gemma":[0.9802588,0.01244908,0.00144773,0.0006107744,0.004050441,0.001183101],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"not_applicable","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0003310915,0.00005568033,0.001508968,0.0003050022,0.00007086447,0.003274755,0.0002962349,0.00008789654,0.0002543533,0.001138474,0.9770378,0.01563887],"study_design_scores_gemma":[0.000511932,0.0003887352,0.003388474,0.001291156,0.0001765155,0.02100612,0.001104112,0.001121454,0.001128399,0.007765202,0.961847,0.0002709697],"study_design_candidate":"not_applicable","study_design_consensus":"not_applicable","genre_codex":"commentary","genre_gemma":"commentary","genre_scores_codex":[0.001291005,0.00257197,0.0003057664,0.9470395,0.04782607,0.00005274105,0.0001571374,0.0001085207,0.000647246],"genre_scores_gemma":[0.008208653,0.001669781,0.0005929326,0.9382435,0.04922258,0.000144475,0.00005114965,0.00003720362,0.001829724],"genre_candidate":"commentary","genre_consensus":"commentary","teacher_disagreement_score":0.02554071,"threshold_uncertainty_score":0.03619683,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0764472983053039,"score_gpt":0.3626413704806529,"score_spread":0.286194072175349,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}