{"id":"W4409176846","doi":"10.1016/j.ymthe.2025.03.060","title":"The advent of clinical self-amplifying RNA vaccines","year":2025,"lang":"en","type":"review","venue":"Molecular Therapy","topic":"SARS-CoV-2 and COVID-19 Research","field":"Medicine","cited_by":71,"is_retracted":false,"has_abstract":false,"ca_institutions":"Canada's Michael Smith Genome Sciences Centre; University of British Columbia","funders":"Natural Sciences and Engineering Research Council of Canada; Korea Research Institute of Bioscience and Biotechnology; Michael Smith Health Research BC; National Research Council of Science and Technology; National Research Foundation of Korea; Canadian Institutes of Health Research; NanoMedicines Innovation Network","keywords":"RNA; Virology; Biology; Computational biology; Genetics; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001407312,0.0003697273,0.001948462,0.0001890194,0.00009936436,0.00003370793,0.0006100636,0.0003857313,0.000008702666],"category_scores_gemma":[0.0003941581,0.0002086025,0.00159297,0.0005652133,0.00006923125,0.00001448936,0.0001365893,0.000780621,0.00004338881],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00006561098,"about_ca_system_score_gemma":0.001546093,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001888618,"about_ca_topic_score_gemma":0.00000157218,"domain_scores_codex":[0.9968362,0.0005562922,0.001182118,0.0004791132,0.000569429,0.0003768077],"domain_scores_gemma":[0.9972185,0.0009968783,0.0003488187,0.001177395,0.0002112298,0.00004711002],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00009741198,0.0001980369,0.00007452908,0.006489596,0.001092712,0.00009867665,0.00001686099,1.383229e-8,0.00008617899,0.0001922743,0.0002569382,0.9913968],"study_design_scores_gemma":[0.0009804096,0.0002442738,0.00001517659,0.005711691,0.0003947143,0.0000184138,0.00000698126,0.000003858539,0.0008300637,0.0001027245,0.9915293,0.0001623233],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0003999948,0.9949956,0.0001957093,0.0001558156,0.0003383031,0.001530342,0.000005161129,0.00006259428,0.002316514],"genre_scores_gemma":[0.00002816962,0.9920952,0.0001550646,0.007119015,0.0002306126,0.0001861529,0.000007281819,0.00006176504,0.0001167706],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.9912724,"threshold_uncertainty_score":0.8506564,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1150164290381519,"score_gpt":0.4909360557312767,"score_spread":0.3759196266931248,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}