{"id":"W4409182721","doi":"10.1002/adhm.202405257","title":"Development of Itaconate Polymers Microparticles for Intracellular Regulation of Pro‐Inflammatory Macrophage Activation","year":2025,"lang":"en","type":"article","venue":"Advanced Healthcare Materials","topic":"RNA Interference and Gene Delivery","field":"Biochemistry, Genetics and Molecular Biology","cited_by":7,"is_retracted":false,"has_abstract":true,"ca_institutions":"Nova Scotia Health Authority; Dalhousie University","funders":"National Institute of Arthritis and Musculoskeletal and Skin Diseases; National Institutes of Health; Research Nova Scotia; Killam Trusts; Dalhousie University; National Institute of Allergy and Infectious Diseases; Natural Sciences and Engineering Research Council of Canada; Dalhousie Medical Research Foundation","keywords":"Intracellular; Microparticle; Internalization; Drug delivery; Phagocytosis; Metabolite; Chemistry; Flow cytometry; Cell biology; Biophysics; Biochemistry; Biology; Materials science; Cell; Nanotechnology; Molecular biology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000148153,0.0003182112,0.0001327841,0.0001854159,0.00008123027,0.0002098785,0.0001839215,0.0002649199,0.0005252881],"category_scores_gemma":[0.0001083866,0.00009903678,0.0001592426,0.00009057686,0.0001261235,0.0001392972,0.0001160101,0.0002294993,0.0002052745],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002818163,"about_ca_system_score_gemma":0.0001196663,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002287478,"about_ca_topic_score_gemma":0.0002395861,"domain_scores_codex":[0.9999408,0.000007775682,0.000005927981,0.00001632196,0.00001721214,0.00001198787],"domain_scores_gemma":[0.9999385,0.00001314566,0.00002103337,0.000004814732,0.00001186106,0.00001063397],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00002563148,0.00001264854,0.00001998774,0.00001748161,0.000001597117,0.00001466025,0.000003192639,0.00008962903,0.9986187,0.00008723282,0.00001876173,0.001090604],"study_design_scores_gemma":[0.000005977977,0.00009879342,0.0001655548,0.000001424136,0.000003229721,0.00002202269,0.000001167286,0.0005207541,0.9984137,0.000009967176,0.0007560641,0.000001367589],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9603568,0.002518602,0.03409478,0.0001105708,0.00007174255,0.0001356824,0.0003172438,0.0002589399,0.002135542],"genre_scores_gemma":[0.9837816,0.0008351008,0.01267789,0.00004084119,0.000013378,0.0001128626,0.0001654101,0.0000281384,0.002344795],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0005252881,"threshold_uncertainty_score":0.002044678,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01267968822440221,"score_gpt":0.2887955310058202,"score_spread":0.276115842781418,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}