{"id":"W4409182721","doi":"10.1002/adhm.202405257","title":"Development of Itaconate Polymers Microparticles for Intracellular Regulation of Pro‐Inflammatory Macrophage Activation","year":2025,"lang":"en","type":"article","venue":"Advanced Healthcare Materials","topic":"RNA Interference and Gene Delivery","field":"Biochemistry, Genetics and Molecular Biology","cited_by":7,"is_retracted":false,"has_abstract":true,"ca_institutions":"Nova Scotia Health Authority; Dalhousie University","funders":"National Institute of Arthritis and Musculoskeletal and Skin Diseases; National Institutes of Health; Research Nova Scotia; Killam Trusts; Dalhousie University; National Institute of Allergy and Infectious Diseases; Natural Sciences and Engineering Research Council of Canada; Dalhousie Medical Research Foundation","keywords":"Intracellular; Microparticle; Internalization; Drug delivery; Phagocytosis; Metabolite; Chemistry; Flow cytometry; Cell biology; Biophysics; Biochemistry; Biology; Materials science; Cell; Nanotechnology; Molecular biology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000170524,0.00009146985,0.0001669867,0.000050108,0.00004666219,0.000004807229,0.00008062768,0.00009152764,0.00001283364],"category_scores_gemma":[0.0000379654,0.00009226746,0.00003182533,0.00004765318,0.00003499193,0.00000737033,0.00003495406,0.00001742069,7.104798e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002036074,"about_ca_system_score_gemma":0.0001549052,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001580429,"about_ca_topic_score_gemma":0.00001563264,"domain_scores_codex":[0.9991343,0.0000377826,0.0004503615,0.0001816767,0.0000566241,0.0001392317],"domain_scores_gemma":[0.9994061,0.00001005168,0.0002201391,0.0001642196,0.0001768007,0.00002267058],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0005113261,0.00002036198,0.00006619323,0.0004972525,0.00003035085,7.682151e-8,0.0001318312,0.00004545568,0.9781998,0.0003003388,0.0000315088,0.02016554],"study_design_scores_gemma":[0.0003724459,0.0000989966,0.002212132,0.0001273626,0.000006316953,2.546458e-7,0.0001308177,0.000005265093,0.9945667,0.0001851971,0.002220271,0.00007418073],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9957461,0.0003958455,0.003014967,0.0001822043,0.0001641329,0.0004402485,0.00003463688,0.000006000371,0.00001585874],"genre_scores_gemma":[0.9930069,0.00004927823,0.006394643,0.00009710479,0.00002729845,0.0000703378,0.0001516497,0.000009579793,0.0001932495],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.02009136,"threshold_uncertainty_score":0.3762558,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01267968822440221,"score_gpt":0.2887955310058202,"score_spread":0.276115842781418,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}