{"id":"W4409188114","doi":"10.1016/j.annonc.2025.03.019","title":"Circulating tumor DNA clearance as a predictive biomarker of pathologic complete response in patients with solid tumors treated with neoadjuvant immune checkpoint inhibitors: a systematic review and meta-analysis","year":2025,"lang":"en","type":"review","venue":"Annals of Oncology","topic":"Cancer Genomics and Diagnostics","field":"Biochemistry, Genetics and Molecular Biology","cited_by":28,"is_retracted":false,"has_abstract":false,"ca_institutions":"Princess Margaret Cancer Centre","funders":"Ministero dell’Istruzione, dell’Università e della Ricerca; European Commission","keywords":"Medicine; Meta-analysis; Biomarker; Oncology; Immune checkpoint; Internal medicine; Immune system; Complete response; Cancer research; Immunotherapy; Chemotherapy; Immunology; Cancer","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.00126972,0.0004857226,0.006912728,0.0003621955,0.00002928515,0.000009416749,0.0002507894,0.0002362338,0.000006418571],"category_scores_gemma":[0.0009935015,0.0003142357,0.0009409845,0.000781492,0.0002518118,0.000005083076,0.0001901708,0.0001718539,5.163329e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00004718745,"about_ca_system_score_gemma":0.0006252897,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00008443961,"about_ca_topic_score_gemma":0.00003763041,"domain_scores_codex":[0.9959339,0.001120269,0.001808195,0.0006630003,0.0001816016,0.0002929773],"domain_scores_gemma":[0.9959882,0.000387902,0.002373423,0.0006955438,0.0004812519,0.00007364082],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"systematic_review","study_design_gemma":"meta_analysis","study_design_scores_codex":[0.006748248,0.001375802,0.0002967834,0.8405455,0.1453319,0.0004513734,0.000150781,0.0001380829,0.0002983725,0.00001485026,0.00007672174,0.004571583],"study_design_scores_gemma":[0.003473247,0.03074084,0.003250878,0.1564474,0.7986153,0.0002701097,0.0001209712,0.00002961245,0.0005454565,0.00002301683,0.004881789,0.00160141],"study_design_candidate":"systematic_review","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0230453,0.9734992,0.00001800327,0.00006346429,0.00001040068,0.00269375,0.000607596,0.000006428832,0.00005584872],"genre_scores_gemma":[0.07690234,0.9217021,0.0001279047,0.0002975547,0.000007657523,0.0005622911,0.0003305191,0.00004673541,0.00002286549],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.6840982,"threshold_uncertainty_score":0.999931,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05169435931246081,"score_gpt":0.3473046035091251,"score_spread":0.2956102441966643,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}