{"id":"W4409189524","doi":"10.1002/em.70006","title":"Benchmark Response (<scp>BMR</scp>) Values for In Vivo Mutagenicity Endpoints","year":2025,"lang":"en","type":"article","venue":"Environmental and Molecular Mutagenesis","topic":"Carcinogens and Genotoxicity Assessment","field":"Biochemistry, Genetics and Molecular Biology","cited_by":12,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Ottawa; Health Canada","funders":"Rijksinstituut voor Volksgezondheid en Milieu; Health Canada","keywords":"In vivo; Clinical endpoint; Statistics; Benchmark (surveying); Toxicology; Biology; Mathematics; Biotechnology; Bioinformatics; Clinical trial","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.02478776,0.001881825,0.001833506,0.003146289,0.0007592393,0.001793512,0.002375544,0.002251935,0.006822526],"category_scores_gemma":[0.02424231,0.0004702799,0.002072208,0.003001428,0.001063811,0.0015129,0.001752056,0.003357052,0.003231799],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001352093,"about_ca_system_score_gemma":0.001456069,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007997657,"about_ca_topic_score_gemma":0.001208927,"domain_scores_codex":[0.9729704,0.01044752,0.002792132,0.002792843,0.0104509,0.000546212],"domain_scores_gemma":[0.9755129,0.01101667,0.002939907,0.004906652,0.005268673,0.0003552272],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.002697342,0.0009244059,0.01856738,0.005786434,0.0006645989,0.0005965442,0.0006412315,0.02297635,0.752804,0.02299644,0.01291483,0.1584305],"study_design_scores_gemma":[0.0001145428,0.008542396,0.03376033,0.0007058681,0.0005265079,0.00152932,0.0004299641,0.01398121,0.8510786,0.01346008,0.0756373,0.0002339487],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"methods","genre_gemma":"empirical","genre_scores_codex":[0.1713819,0.0139278,0.7422809,0.001068801,0.0006955542,0.004063401,0.02009948,0.003459094,0.043023],"genre_scores_gemma":[0.6188814,0.005327896,0.3382603,0.001784286,0.0001678624,0.007468527,0.01422969,0.001498426,0.01238164],"genre_candidate":"empirical","genre_consensus":null,"teacher_disagreement_score":0.02478776,"threshold_uncertainty_score":0.1310917,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.003860128171325241,"score_gpt":0.2289415043603192,"score_spread":0.2250813761889939,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}