{"id":"W4409189524","doi":"10.1002/em.70006","title":"Benchmark Response (<scp>BMR</scp>) Values for In Vivo Mutagenicity Endpoints","year":2025,"lang":"en","type":"article","venue":"Environmental and Molecular Mutagenesis","topic":"Carcinogens and Genotoxicity Assessment","field":"Biochemistry, Genetics and Molecular Biology","cited_by":12,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Ottawa; Health Canada","funders":"Rijksinstituut voor Volksgezondheid en Milieu; Health Canada","keywords":"In vivo; Clinical endpoint; Statistics; Benchmark (surveying); Toxicology; Biology; Mathematics; Biotechnology; Bioinformatics; Clinical trial","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0003670843,0.0002553811,0.0002240412,0.0001132571,0.0001294395,0.0000312784,0.0001583727,0.0001782268,0.00002336528],"category_scores_gemma":[0.00006887298,0.0002731927,0.0001711452,0.00007716138,0.0001265797,0.000005675534,0.0002573138,0.00006703858,0.000003734165],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00006168162,"about_ca_system_score_gemma":0.00004421806,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0000175664,"about_ca_topic_score_gemma":0.00002030753,"domain_scores_codex":[0.9984914,0.0001431899,0.0002595343,0.0006072125,0.0001421254,0.000356533],"domain_scores_gemma":[0.9994265,0.00006100641,0.00005759539,0.0003488345,0.000007304731,0.00009877632],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001958034,0.0001529665,0.005454183,0.00002794631,0.0000833784,0.00002335365,0.00007119283,0.00006881635,0.9920348,0.00003428787,0.0007188076,0.001134476],"study_design_scores_gemma":[0.001033654,0.0002389026,0.04352359,0.00001292446,0.00005242665,0.000009909904,0.0003631993,0.00006681112,0.9247434,0.0001654162,0.02965312,0.0001366615],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9931763,0.002296186,0.003115387,0.0001076979,0.00009854223,0.0005675168,0.0001801137,0.000009221902,0.0004489705],"genre_scores_gemma":[0.9947218,0.0003691762,0.001133882,0.0008368948,0.00003382639,0.0001501248,0.0001082436,0.00002658167,0.002619497],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.06729141,"threshold_uncertainty_score":0.999972,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.003860128171325241,"score_gpt":0.2289415043603192,"score_spread":0.2250813761889939,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}