{"id":"W4409191092","doi":"10.1016/j.stemcr.2025.102471","title":"Large-scale analysis of loss of chromosome Y in human pluripotent stem cells: Implications for Turner syndrome and ribosomopathies","year":2025,"lang":"en","type":"article","venue":"Stem Cell Reports","topic":"Genetic and Clinical Aspects of Sex Determination and Chromosomal Abnormalities","field":"Biochemistry, Genetics and Molecular Biology","cited_by":5,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"United States-Israel Binational Science Foundation; Rosetrees Trust; European Commission; HORIZON EUROPE European Research Council; Azrieli Foundation; Israel Science Foundation; United States - Israel Binational Science Foundation","keywords":"Biology; Induced pluripotent stem cell; Turner syndrome; Scale (ratio); Genetics; Stem cell; Karyotype; Chromosome; Evolutionary biology; Embryonic stem cell; Gene","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002143402,0.0001561824,0.0001248812,0.0003494961,0.0001334805,0.0002340432,0.00007002125,0.000139037,0.0004675437],"category_scores_gemma":[0.0002840087,0.0000687832,0.0001477621,0.000196529,0.0001384814,0.00007393453,0.0002013324,0.0001939199,0.0001271066],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001083224,"about_ca_system_score_gemma":0.0001644556,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004824265,"about_ca_topic_score_gemma":0.001196169,"domain_scores_codex":[0.9998876,0.00001126135,0.000009067283,0.00003184782,0.00004937232,0.00001086255],"domain_scores_gemma":[0.9998505,0.00005764261,0.00003845715,0.00001764009,0.00001974953,0.00001587408],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.00003196632,0.000003324774,0.006904738,0.00004020371,0.00001572343,0.0001123613,0.00003307392,0.0001976693,0.9880513,0.00005694304,0.00003811286,0.004514694],"study_design_scores_gemma":[0.000006927342,0.0001234801,0.256533,0.00002143419,0.0000951652,0.0009854157,0.0001877068,0.002676317,0.7344169,0.0002799535,0.004662856,0.00001087922],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9871442,0.001998953,0.008662236,0.00006619854,0.00001792963,0.00001804921,0.001352682,0.00007046469,0.0006693025],"genre_scores_gemma":[0.9916065,0.0008818986,0.004587781,0.00008386154,0.000007781347,0.00002397939,0.001991068,0.00003167228,0.0007853481],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0004824265,"threshold_uncertainty_score":0.001564085,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008860784670617884,"score_gpt":0.2616190820585246,"score_spread":0.2527582973879067,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}