{"id":"W4409196613","doi":"10.1016/j.coi.2025.102554","title":"Pharmacotherapeutic strategies to promote regulatory T cell function in autoimmunity","year":2025,"lang":"en","type":"review","venue":"Current Opinion in Immunology","topic":"Immune Cell Function and Interaction","field":"Immunology and Microbiology","cited_by":7,"is_retracted":false,"has_abstract":false,"ca_institutions":"BC Children's Hospital","funders":"National Institute of Allergy and Infectious Diseases; Canadian Institutes of Health Research; National Institutes of Health; BC Children's Hospital; Canadian Society of Transplantation; Office of Extramural Research, National Institutes of Health; U.S. Department of Defense","keywords":"Autoimmunity; Regulatory T cell; Function (biology); Biology; Computational biology; T cell; Cell biology; Genetics; Immune system","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","research_integrity","insufficient_payload"],"consensus_categories":["insufficient_payload"],"category_scores_codex":[0.0005323672,0.000702379,0.001696844,0.002152893,0.0001483905,0.00004540189,0.0006128189,0.001022465,0.001147652],"category_scores_gemma":[0.00005491487,0.0006876248,0.0003884785,0.001145125,0.0001628909,0.0002525604,0.0002743637,0.002608494,0.001698433],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006203617,"about_ca_system_score_gemma":0.0008714982,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00008848189,"about_ca_topic_score_gemma":0.00001036998,"domain_scores_codex":[0.9955003,0.001481516,0.001463194,0.0007959023,0.00005649755,0.0007026399],"domain_scores_gemma":[0.9984143,0.0002524991,0.0004720469,0.000750288,0.00008931521,0.00002155412],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0002725472,0.000699434,0.00001365865,0.009787792,0.0002114312,6.914454e-7,0.0003021753,0.00001032119,0.0009466394,0.0007144985,0.006740304,0.9803005],"study_design_scores_gemma":[0.00126124,0.0002550526,0.0002207836,0.01332066,0.000117895,0.00002359313,0.0001818283,0.0000014562,0.00009216813,0.000067762,0.9839347,0.0005228508],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0001001374,0.9276815,0.0001354714,0.00003319106,0.0693213,0.001540179,0.00001423958,0.0001343883,0.001039556],"genre_scores_gemma":[0.000239841,0.9942819,0.000007197215,0.00003508041,0.00008609452,0.0006462138,0.001056215,0.00005067851,0.003596798],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.9797776,"threshold_uncertainty_score":0.9997655,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05859741849847949,"score_gpt":0.3685198308740951,"score_spread":0.3099224123756156,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}