{"id":"W4409202065","doi":"10.1016/j.ejca.2025.115395","title":"Pembrolizumab with or without chemotherapy in recurrent or metastatic head and neck squamous cell carcinoma: 5-year follow-up from the randomized phase III KEYNOTE-048 study","year":2025,"lang":"en","type":"article","venue":"European Journal of Cancer","topic":"Head and Neck Cancer Studies","field":"Medicine","cited_by":28,"is_retracted":false,"has_abstract":false,"ca_institutions":"Centre Hospitalier de l’Université de Montréal","funders":"","keywords":"Medicine; Pembrolizumab; Head and neck; Chemotherapy; Oncology; Basal cell; Internal medicine; Surgery; Cancer; Immunotherapy","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00447544,0.001642899,0.00366409,0.0004548103,0.0006818423,0.001462668,0.001130663,0.001755511,0.004348408],"category_scores_gemma":[0.002698102,0.0007095558,0.004051636,0.0006320986,0.001115863,0.001858422,0.0006138412,0.003661078,0.0008644974],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001380829,"about_ca_system_score_gemma":0.001238796,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002107615,"about_ca_topic_score_gemma":0.004330169,"domain_scores_codex":[0.9983595,0.0008497773,0.00008599077,0.0002568249,0.0001328677,0.000315029],"domain_scores_gemma":[0.9984169,0.0004406192,0.0004427493,0.0002234479,0.0001129459,0.0003633052],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.9688064,0.003944947,0.002567254,0.0005720333,0.004241559,0.00005636637,0.00005613387,0.0006097206,0.001775239,0.00008296459,0.001117755,0.01616976],"study_design_scores_gemma":[0.8422351,0.12177,0.02486206,0.0001281737,0.007335677,0.0001134554,0.00009566672,0.0005428502,0.0008981672,0.0002649041,0.001712013,0.00004186155],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9865041,0.007440513,0.0004903052,0.0003987604,0.0003134442,0.001018788,0.002058389,0.00005328447,0.001722633],"genre_scores_gemma":[0.9886905,0.0031145,0.0004785946,0.0009495487,0.0002982569,0.00103196,0.003068313,0.00002797992,0.002340212],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00447544,"threshold_uncertainty_score":0.02366871,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0300769779812097,"score_gpt":0.3364075608723345,"score_spread":0.3063305828911248,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}