{"id":"W4409203336","doi":"10.1016/j.ijgc.2025.101812","title":"Randomized study evaluating optimal dose, efficacy, and safety of E7386 plus lenvatinib versus treatment of physician’s choice in advanced/recurrent endometrial carcinoma previously treated with platinum-based chemotherapy and immune checkpoint inhibitors","year":2025,"lang":"en","type":"article","venue":"International Journal of Gynecological Cancer","topic":"Endometrial and Cervical Cancer Treatments","field":"Medicine","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"Sunnybrook Health Science Centre","funders":"Eisai Incorporated; Eisai Canada; AbbVie","keywords":"Medicine; Lenvatinib; Oncology; Chemotherapy; Internal medicine; Randomized controlled trial; Sorafenib","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.005524746,0.001411464,0.004443658,0.0005536801,0.0005866787,0.001432658,0.001059251,0.002542343,0.008715273],"category_scores_gemma":[0.006162053,0.0009243257,0.003336673,0.0005914115,0.00173348,0.0015098,0.0007127574,0.0043336,0.0008349403],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001454903,"about_ca_system_score_gemma":0.002299382,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00112582,"about_ca_topic_score_gemma":0.002382232,"domain_scores_codex":[0.9963404,0.002393786,0.0002601664,0.0004387745,0.000210441,0.0003564382],"domain_scores_gemma":[0.9951347,0.00184452,0.001246443,0.0003582351,0.0003211843,0.001095043],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.9922822,0.002925936,0.0002706008,0.0001781006,0.0006905113,0.00001181335,0.00001066913,0.0001297455,0.0003003788,0.00004393041,0.000191205,0.002965076],"study_design_scores_gemma":[0.9361685,0.06145013,0.0007369108,0.00002574205,0.0006222137,0.00001364853,0.000009341772,0.0003333088,0.0001412335,0.0001271737,0.0003631058,0.000008728557],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9650608,0.006560669,0.001656908,0.001572956,0.00167388,0.01779669,0.001773747,0.0001558411,0.003748506],"genre_scores_gemma":[0.9783785,0.001622945,0.002249532,0.001734923,0.0006223961,0.01206021,0.0008993443,0.00002173464,0.002410437],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.008715273,"threshold_uncertainty_score":0.02921796,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04268350615576826,"score_gpt":0.3771761306306152,"score_spread":0.334492624474847,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}