{"id":"W4409212271","doi":"10.1093/neuonc/noaf092","title":"Salvage therapies for first relapse of SHH medulloblastoma in early childhood","year":2025,"lang":"en","type":"article","venue":"Neuro-Oncology","topic":"Glioma Diagnosis and Treatment","field":"Medicine","cited_by":3,"is_retracted":false,"has_abstract":true,"ca_institutions":"SickKids Foundation; Université de Montréal; Hospital for Sick Children; BC Children's Hospital; Université Laval; University of British Columbia; London Health Sciences Centre; University of Toronto; Western University; Nova Scotia Health Authority; Izaak Walton Killam Health Centre; Alberta Children's Hospital; University of Calgary; Children's Hospital of Western Ontario; Centre Hospitalier Universitaire Sainte-Justine; Dalhousie University","funders":"","keywords":"Medicine; Medulloblastoma; Hazard ratio; Vismodegib; Radiation therapy; Oncology; Proportional hazards model; Internal medicine; Chemotherapy; Salvage therapy; Cohort; Surgery; Pathology; Confidence interval","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000277105,0.0001677757,0.0005064937,0.0003173103,0.00015528,0.0002683994,0.0003453286,0.0001822484,0.001033661],"category_scores_gemma":[0.000795072,0.00007981064,0.0005333295,0.0003587784,0.0001827083,0.0001552239,0.0002500058,0.0004829045,0.0001559128],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0007658558,"about_ca_system_score_gemma":0.0004964257,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001775161,"about_ca_topic_score_gemma":0.00395992,"domain_scores_codex":[0.9998143,0.0000294794,0.00001426488,0.00003434508,0.00005654291,0.00005107549],"domain_scores_gemma":[0.9994332,0.00007438433,0.0003510936,0.00002332925,0.00002571922,0.00009225754],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.001231924,0.0002300274,0.9264782,0.0002969937,0.0003392359,0.003221392,0.0002019486,0.0009425819,0.002499911,0.0002114352,0.00176687,0.0625794],"study_design_scores_gemma":[0.00009332195,0.001505159,0.9772898,0.0002084626,0.0002692514,0.01232063,0.0002695199,0.001549332,0.002691267,0.0004435164,0.003347982,0.00001168041],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.993418,0.004793384,0.0003627857,0.0001687813,0.0000190874,0.00001994311,0.0003527336,0.00002725123,0.0008380744],"genre_scores_gemma":[0.9970604,0.001843566,0.0002017258,0.00008531756,0.00002578436,0.00001171536,0.0005362945,0.000005828968,0.0002294042],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001775161,"threshold_uncertainty_score":0.005556703,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01150137227333072,"score_gpt":0.2832886623959961,"score_spread":0.2717872901226654,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}