{"id":"W4409212271","doi":"10.1093/neuonc/noaf092","title":"Salvage therapies for first relapse of SHH medulloblastoma in early childhood","year":2025,"lang":"en","type":"article","venue":"Neuro-Oncology","topic":"Glioma Diagnosis and Treatment","field":"Medicine","cited_by":3,"is_retracted":false,"has_abstract":true,"ca_institutions":"SickKids Foundation; Université de Montréal; Hospital for Sick Children; BC Children's Hospital; Université Laval; University of British Columbia; London Health Sciences Centre; University of Toronto; Western University; Nova Scotia Health Authority; Izaak Walton Killam Health Centre; Alberta Children's Hospital; University of Calgary; Children's Hospital of Western Ontario; Centre Hospitalier Universitaire Sainte-Justine; Dalhousie University","funders":"","keywords":"Medicine; Medulloblastoma; Hazard ratio; Vismodegib; Radiation therapy; Oncology; Proportional hazards model; Internal medicine; Chemotherapy; Salvage therapy; Cohort; Surgery; Pathology; Confidence interval","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00011476,0.0001376345,0.0004721505,0.0002506996,0.00004148415,0.000004730256,0.0000901776,0.0001494876,0.00003642643],"category_scores_gemma":[0.0002482369,0.0001129692,0.0001303288,0.0002527047,0.00007860164,0.00002949734,0.0000427437,0.0001410258,0.000009298813],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001109629,"about_ca_system_score_gemma":0.0001745667,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00004725298,"about_ca_topic_score_gemma":0.0003011222,"domain_scores_codex":[0.9990298,0.00005686223,0.000323339,0.0002652887,0.00009332138,0.0002313936],"domain_scores_gemma":[0.9987581,0.0007831807,0.00009168342,0.0002539709,0.00005722086,0.00005585411],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.002088685,0.01128268,0.63669,0.0003566347,0.0008197763,0.0008773592,0.009302312,0.00003402655,0.1856295,0.01228074,0.02193255,0.1187058],"study_design_scores_gemma":[0.01322706,0.005077033,0.8248393,0.000161467,0.0002262626,0.00003685624,0.0002683819,0.00003084732,0.05266761,0.000983402,0.1023643,0.0001174733],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9828456,0.0007931862,0.00001261745,0.01262507,0.0003464792,0.0008814635,0.00001492174,0.00003267705,0.002447977],"genre_scores_gemma":[0.9975229,0.0001653295,0.0003386668,0.001568669,0.00004787338,0.000298013,0.000008239103,0.00001772918,0.00003257505],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1881493,"threshold_uncertainty_score":0.4606752,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01150137227333072,"score_gpt":0.2832886623959961,"score_spread":0.2717872901226654,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}