{"id":"W4409213551","doi":"10.3390/toxins17040182","title":"Computational Immunogenetic Analysis of Botulinum Toxin A Immunogenicity and HLA Gene Haplotypes: New Insights","year":2025,"lang":"en","type":"article","venue":"Toxins","topic":"Botulinum Toxin and Related Neurological Disorders","field":"Medicine","cited_by":17,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia","funders":"","keywords":"Immunogenicity; Epitope; Human leukocyte antigen; Biology; In silico; Haplotype; Genetics; Allele; Immunology; Immune system; Antibody; Gene; Virology; Antigen","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004201703,0.0007163836,0.001007567,0.0006469162,0.0004328732,0.0008380225,0.0009774119,0.000961109,0.002274629],"category_scores_gemma":[0.001501952,0.0004470452,0.0009765662,0.0005772389,0.0003191068,0.000492195,0.0006113516,0.0006451999,0.0002013579],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004481567,"about_ca_system_score_gemma":0.001167489,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.01051385,"about_ca_topic_score_gemma":0.00908129,"domain_scores_codex":[0.9998821,0.00004469561,0.000006345979,0.00001857244,0.00002373736,0.00002459343],"domain_scores_gemma":[0.9994853,0.0003437901,0.00003209173,0.00003312675,0.00005496505,0.00005083664],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"simulation_or_modeling","study_design_gemma":"observational","study_design_scores_codex":[0.0001390146,0.0001393476,0.00677511,0.0001127532,0.0001439713,0.0001797389,0.00004139016,0.981741,0.001028047,0.002488877,0.001032937,0.006177745],"study_design_scores_gemma":[0.00002170618,0.00002030669,0.0005333767,0.000004897054,0.00001813477,0.00001186489,0.00001792343,0.9978751,0.0001097752,0.001069076,0.000313928,0.000003863086],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9480273,0.001196885,0.03956969,0.001031801,0.0001363608,0.0000779773,0.001581243,0.0006783024,0.007700367],"genre_scores_gemma":[0.9747363,0.0005266932,0.02089761,0.0002968784,0.00005221274,0.0001599629,0.001854269,0.0001384514,0.001337718],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01051385,"threshold_uncertainty_score":0.02090532,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01137979392660819,"score_gpt":0.263087889242033,"score_spread":0.2517080953154248,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}