{"id":"W4409213551","doi":"10.3390/toxins17040182","title":"Computational Immunogenetic Analysis of Botulinum Toxin A Immunogenicity and HLA Gene Haplotypes: New Insights","year":2025,"lang":"en","type":"article","venue":"Toxins","topic":"Botulinum Toxin and Related Neurological Disorders","field":"Medicine","cited_by":17,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia","funders":"","keywords":"Immunogenicity; Epitope; Human leukocyte antigen; Biology; In silico; Haplotype; Genetics; Allele; Immunology; Immune system; Antibody; Gene; Virology; Antigen","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00007302965,0.0001746036,0.0005335534,0.0003954922,0.00007705639,0.00001258266,0.0001129216,0.0002032324,0.0001831564],"category_scores_gemma":[0.00006776337,0.0001401859,0.0002450836,0.001294561,0.0001715267,0.00003037588,0.00008564389,0.0002300309,0.0000131686],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002534967,"about_ca_system_score_gemma":0.0001621358,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001051357,"about_ca_topic_score_gemma":0.00003113852,"domain_scores_codex":[0.99879,0.00006051785,0.0004298036,0.0003275117,0.0001976945,0.0001944312],"domain_scores_gemma":[0.9992959,0.0001338152,0.00009213454,0.0002837637,0.00007502401,0.0001192923],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.006034845,0.004697509,0.1060098,0.0005228715,0.04154456,0.0002933664,0.004331846,0.06108593,0.6953372,0.01942041,0.005119157,0.0556025],"study_design_scores_gemma":[0.005140867,0.0007450317,0.9302503,0.00009235476,0.005617838,0.00002516929,0.0001158472,0.03463626,0.01377552,0.006281965,0.002972227,0.0003465629],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9857891,0.007689184,0.002759386,0.001235912,0.00008167461,0.0002508707,0.00001205196,0.00006274454,0.002119106],"genre_scores_gemma":[0.9945479,0.0009660794,0.001595133,0.001466898,0.00001554895,0.000004247472,0.00005260179,0.00001112451,0.001340482],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.8242405,"threshold_uncertainty_score":0.5716617,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01137979392660819,"score_gpt":0.263087889242033,"score_spread":0.2517080953154248,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}