{"id":"W4409213948","doi":"10.1128/jvi.00062-25","title":"Safety, pharmacokinetics, and biological activity of CD4-mimetic BNM-III-170 in SHIV-infected rhesus macaques","year":2025,"lang":"en","type":"article","venue":"Journal of Virology","topic":"HIV Research and Treatment","field":"Immunology and Microbiology","cited_by":3,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Montréal","funders":"National Institute of Allergy and Infectious Diseases; National Institutes of Health","keywords":"Pharmacokinetics; Antibody; Antibody-dependent cell-mediated cytotoxicity; Biology; Epitope; Virology; Glycoprotein; Pharmacology; Immunology; Molecular biology; Monoclonal antibody","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002754138,0.0003400197,0.0003784869,0.0002006572,0.0001804776,0.0002396709,0.000185543,0.0002453304,0.0007022129],"category_scores_gemma":[0.0003560302,0.0001178222,0.0001970213,0.000083671,0.0002633279,0.0001711684,0.0000826426,0.0004857009,0.0002461286],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003377354,"about_ca_system_score_gemma":0.0002875413,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002331973,"about_ca_topic_score_gemma":0.001794375,"domain_scores_codex":[0.9998901,0.00003360701,0.000007233506,0.00001608911,0.00002448364,0.00002852432],"domain_scores_gemma":[0.9998118,0.00003998242,0.00004440531,0.00002611295,0.00003303264,0.00004466116],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.008268114,0.001253991,0.002748104,0.0001206154,0.00004816993,0.0002382128,0.0002121993,0.0003859052,0.9712636,0.0001078667,0.0003841006,0.01496902],"study_design_scores_gemma":[0.001180272,0.1486928,0.08846991,0.00004745993,0.0002674931,0.001504288,0.0003961871,0.004532941,0.7460846,0.0002016361,0.008567612,0.00005480299],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9985575,0.0005592263,0.0002162535,0.00002808899,0.000007642064,0.00004178185,0.0001701447,0.00002792433,0.0003915076],"genre_scores_gemma":[0.9977176,0.0004040137,0.0004779904,0.00004832557,0.00001514156,0.00008017266,0.0003728117,0.00001142268,0.0008725976],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002331973,"threshold_uncertainty_score":0.004636824,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01533267499669048,"score_gpt":0.3101446517122603,"score_spread":0.2948119767155698,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}