{"id":"W4409214923","doi":"10.54985/peeref.2504a2018995","title":"The Role of Biomarkers in Guiding Adjuvant Systemic Therapy Decisions for Early-Stage Invasive Breast Cancer","year":2025,"lang":"en","type":"article","venue":"","topic":"Breast Cancer Treatment Studies","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":false,"ca_institutions":"George Brown College","funders":"","keywords":"Systemic therapy; Stage (stratigraphy); Breast cancer; Adjuvant; Oncology; Adjuvant therapy; Medicine; Internal medicine; Cancer; Biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.004548231,0.0006546302,0.0008329569,0.001765162,0.0003619767,0.002596802,0.0004198091,0.0006887577,0.000983411],"category_scores_gemma":[0.008288126,0.0002903092,0.0003605964,0.001670339,0.0005901044,0.001101451,0.0004000316,0.0008425291,0.0002984853],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0007914539,"about_ca_system_score_gemma":0.001144995,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001826119,"about_ca_topic_score_gemma":0.002722193,"domain_scores_codex":[0.9989587,0.0005840166,0.00009451493,0.00008440441,0.000195261,0.00008301908],"domain_scores_gemma":[0.996707,0.001744955,0.0006979728,0.0001595351,0.0005422648,0.0001483138],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.005988439,0.0004420302,0.6659313,0.0007467837,0.0005403999,0.000379769,0.0001820024,0.003231253,0.02101524,0.002549098,0.002889217,0.2961044],"study_design_scores_gemma":[0.000550758,0.005426882,0.8290815,0.001534941,0.002285472,0.003199985,0.001272052,0.01856842,0.06636304,0.01362219,0.05792805,0.0001667575],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.7529816,0.2165431,0.009030049,0.005694054,0.0007222995,0.0001582105,0.001233379,0.000129095,0.0135083],"genre_scores_gemma":[0.9739527,0.01723818,0.006134095,0.0006921619,0.0002852079,0.00006211399,0.000383419,0.00002198555,0.001230131],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004548231,"threshold_uncertainty_score":0.02405363,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01570875851006678,"score_gpt":0.2857723314703882,"score_spread":0.2700635729603214,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}