{"id":"W4409221857","doi":"10.1161/atvb.39.suppl_1.671","title":"Abstract 671: Hepatic Expression of C-Reactive Protein is Epigenetically Regulated by BET Proteins and Inhibited by Apabetalone (RVX-208) <i>in vitro</i> and in CVD Patients","year":2019,"lang":"en","type":"article","venue":"Arteriosclerosis Thrombosis and Vascular Biology","topic":"Protein Degradation and Inhibitors","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Resverlogix (Canada)","funders":"","keywords":"In vitro; Cell biology; Chemistry; Protein expression; Bromodomain; Biology; Molecular biology; Cancer research; Biochemistry; Epigenetics; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00007297825,0.0003050399,0.0002490088,0.000124984,0.0001037476,0.00016293,0.0001060728,0.0001578858,0.003282565],"category_scores_gemma":[0.00005720783,0.00009748004,0.000233989,0.0001148113,0.0001491148,0.00007981171,0.0001199809,0.0004911644,0.0007625017],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001338027,"about_ca_system_score_gemma":0.0001271476,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003485725,"about_ca_topic_score_gemma":0.0003963673,"domain_scores_codex":[0.9999392,0.000009192321,0.00000604481,0.00001087199,0.00001472738,0.00001984951],"domain_scores_gemma":[0.9999661,0.000004318841,0.00001034097,0.000003551139,0.000003832084,0.00001182157],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0006322101,0.00006626787,0.0002364825,0.00003708053,0.000006758065,0.00006218496,0.000006581085,0.00002465405,0.9965441,0.00003460939,0.00009418438,0.002254875],"study_design_scores_gemma":[0.0001093259,0.001663351,0.008955762,0.000006449052,0.00002639219,0.0003525624,0.00001669109,0.0003683216,0.9858671,0.0000322687,0.002597314,0.000004379322],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9941096,0.001999369,0.001344974,0.0001481614,0.00006325093,0.00002994306,0.000606147,0.0001038504,0.00159469],"genre_scores_gemma":[0.9926581,0.0009166372,0.00084061,0.0001091732,0.00002192712,0.00003851359,0.001186967,0.0000168391,0.004211279],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003282565,"threshold_uncertainty_score":0.01098132,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.006253519682683966,"score_gpt":0.2177450404639794,"score_spread":0.2114915207812954,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}