{"id":"W4409222012","doi":"10.1002/ange.202503678","title":"A Single‐Molecule Liposome Assay for Membrane Permeabilization","year":2025,"lang":"en","type":"article","venue":"Angewandte Chemie","topic":"Advanced biosensing and bioanalysis techniques","field":"Biochemistry, Genetics and Molecular Biology","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"Aptose Biosciences (Canada)","funders":"UK Dementia Research Institute; Leverhulme Trust","keywords":"Liposome; Chemistry; Membrane; Molecule; Biophysics; Combinatorial chemistry; Biochemistry; Organic chemistry; Biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0007521197,0.0008605508,0.0004665126,0.0007993513,0.0003839581,0.0004785027,0.0007191913,0.0008953456,0.00253468],"category_scores_gemma":[0.0006266694,0.0002734379,0.0003205115,0.0003147889,0.0004610419,0.0006127981,0.0005699878,0.001019473,0.001102294],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000501762,"about_ca_system_score_gemma":0.0006109201,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003593197,"about_ca_topic_score_gemma":0.0004446177,"domain_scores_codex":[0.9993074,0.0001412574,0.00006285743,0.0002276351,0.0001859526,0.00007487035],"domain_scores_gemma":[0.9992951,0.0002757161,0.0001180219,0.00007771184,0.000155266,0.00007811635],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00001514209,0.00001450447,0.00006607195,0.00003302528,0.000003639527,0.000008436031,0.000008016867,0.0000311106,0.9986945,0.0001329791,0.00006288345,0.0009295875],"study_design_scores_gemma":[0.000004016538,0.00007210032,0.0003947875,0.000005240856,0.000006324206,0.00005725098,0.000006657516,0.001472629,0.9971189,0.00004218223,0.0008144217,0.000005477348],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"methods","genre_scores_codex":[0.4931561,0.004594099,0.4899141,0.0005385646,0.0003213093,0.0009559619,0.002605489,0.002140936,0.005773488],"genre_scores_gemma":[0.7614074,0.002199879,0.2277693,0.0002520272,0.0000664236,0.001251532,0.001781399,0.0001538958,0.005118107],"genre_candidate":"methods","genre_consensus":null,"teacher_disagreement_score":0.00253468,"threshold_uncertainty_score":0.008479357,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01195564646631267,"score_gpt":0.2725170112272727,"score_spread":0.2605613647609601,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}