{"id":"W4409225143","doi":"10.1038/s41421-025-00778-0","title":"Targeting Viperin prevents coxsackievirus B3-induced acute heart failure","year":2025,"lang":"en","type":"article","venue":"Cell Discovery","topic":"Viral Infections and Immunology Research","field":"Medicine","cited_by":4,"is_retracted":false,"has_abstract":true,"ca_institutions":"London Health Sciences Centre; Lawson Health Research Institute; Western University","funders":"Institute of Zoology, Chinese Academy of Sciences; Priority Academic Program Development of Jiangsu Higher Education Institutions; Fudan University; China Postdoctoral Science Foundation; Chinese Academy of Sciences; National Natural Science Foundation of China; China Pharmaceutical University; Fujian Medical University; Soochow University; University of Pennsylvania; Yale University","keywords":"Coxsackievirus; Heart failure; Small interfering RNA; STAT1; Cell biology; Signal transduction; Medicine; Cancer research; Chemistry; Virology; Biology; Virus; Internal medicine; Transfection; Gene; Enterovirus; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001483868,0.0001433784,0.0002704104,0.0001530143,0.0001756092,0.00006623129,0.00010136,0.000137479,0.0001957677],"category_scores_gemma":[0.00006978744,0.0001214743,0.0001367258,0.0003273725,0.00007047419,0.0002616871,0.0001433076,0.0004265824,0.0002595596],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00008428411,"about_ca_system_score_gemma":0.00019001,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00008139446,"about_ca_topic_score_gemma":0.000003234273,"domain_scores_codex":[0.9989636,0.00006732838,0.0002173908,0.0002788823,0.0001321829,0.0003406128],"domain_scores_gemma":[0.9994879,0.00004008725,0.00003268862,0.0003285801,0.00005310573,0.00005761384],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001322727,0.0002715401,0.01231953,0.0001042533,0.0001726653,0.00002213383,0.0000346329,0.000004804543,0.9606289,0.00009369607,0.02522516,0.000990405],"study_design_scores_gemma":[0.003963999,0.001026294,0.05787917,0.0004590508,0.0003261967,0.00003873418,0.0006202333,0.0003063622,0.762071,0.0001709912,0.1726949,0.0004430805],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9870631,0.0008892955,0.0002969859,0.001357305,0.0004550506,0.0003786641,0.000009401334,0.00006019046,0.009490032],"genre_scores_gemma":[0.9693025,0.0001877649,0.0001763629,0.0004757482,0.00007478402,0.00004521614,0.00004019577,0.00001693735,0.02968051],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1985579,"threshold_uncertainty_score":0.4953577,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0135215048393309,"score_gpt":0.3132104311031105,"score_spread":0.2996889262637796,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}