{"id":"W4409225143","doi":"10.1038/s41421-025-00778-0","title":"Targeting Viperin prevents coxsackievirus B3-induced acute heart failure","year":2025,"lang":"en","type":"article","venue":"Cell Discovery","topic":"Viral Infections and Immunology Research","field":"Medicine","cited_by":4,"is_retracted":false,"has_abstract":true,"ca_institutions":"London Health Sciences Centre; Lawson Health Research Institute; Western University","funders":"Institute of Zoology, Chinese Academy of Sciences; Priority Academic Program Development of Jiangsu Higher Education Institutions; Fudan University; China Postdoctoral Science Foundation; Chinese Academy of Sciences; National Natural Science Foundation of China; China Pharmaceutical University; Fujian Medical University; Soochow University; University of Pennsylvania; Yale University","keywords":"Coxsackievirus; Heart failure; Small interfering RNA; STAT1; Cell biology; Signal transduction; Medicine; Cancer research; Chemistry; Virology; Biology; Virus; Internal medicine; Transfection; Gene; Enterovirus; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001669336,0.0003087166,0.0004535381,0.0001961086,0.0001526083,0.000243577,0.0001829586,0.0003432393,0.000847981],"category_scores_gemma":[0.000109219,0.00009951495,0.0001856228,0.00008689283,0.0002472628,0.0001503615,0.0001700641,0.0008207388,0.0001826414],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001852116,"about_ca_system_score_gemma":0.000196128,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003668799,"about_ca_topic_score_gemma":0.0005582575,"domain_scores_codex":[0.9999076,0.00001435301,0.000009334282,0.00001617255,0.00001638593,0.00003618483],"domain_scores_gemma":[0.9999179,0.00001232472,0.00002458758,0.00000540622,0.000005342859,0.00003452168],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0007613376,0.0001839358,0.0001860239,0.00007339654,0.00001147005,0.00005177643,0.00001522217,0.0001010033,0.9945661,0.00009662296,0.00008807912,0.003865049],"study_design_scores_gemma":[0.0003475115,0.004822788,0.008626919,0.0000241717,0.00005123224,0.0003706774,0.00004753841,0.001748869,0.9802669,0.0001090053,0.003572939,0.00001149176],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9957421,0.001494985,0.001504065,0.00009876878,0.00005906557,0.00003932019,0.0001566901,0.00008847549,0.0008164682],"genre_scores_gemma":[0.9959382,0.0008800433,0.001771501,0.0001130379,0.00002010717,0.00003265547,0.0002634081,0.00002134278,0.0009597267],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.000847981,"threshold_uncertainty_score":0.002836823,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0135215048393309,"score_gpt":0.3132104311031105,"score_spread":0.2996889262637796,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}