{"id":"W4409226019","doi":"10.1016/j.slasd.2025.100229","title":"ATPase activity profiling of three human DExD/H-box RNA helicases","year":2025,"lang":"en","type":"article","venue":"SLAS DISCOVERY","topic":"RNA Research and Splicing","field":"Biochemistry, Genetics and Molecular Biology","cited_by":3,"is_retracted":false,"has_abstract":true,"ca_institutions":"Structural Genomics Consortium; University of Toronto","funders":"National Institute on Aging","keywords":"Helicase; Profiling (computer programming); Computational biology; RNA Helicase A; Biology; ATPase; RNA; Virology; Cell biology; Genetics; Computer science; Enzyme; Biochemistry; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001077566,0.000109197,0.0001440253,0.00005676441,0.0000933813,0.00003444995,0.0001758076,0.0000807622,0.00000602267],"category_scores_gemma":[0.000127503,0.00009766945,0.0001111923,0.0001084804,0.00009693388,0.00001162651,0.0001932769,0.00009512209,0.000002779155],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001497527,"about_ca_system_score_gemma":0.0001322513,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001618926,"about_ca_topic_score_gemma":0.0002820949,"domain_scores_codex":[0.9992009,0.00003727564,0.000139246,0.0002608265,0.0001268453,0.000234947],"domain_scores_gemma":[0.9994696,0.00002139894,0.00005192114,0.0003609841,0.00005052426,0.00004558101],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001204931,0.00008235293,0.01354767,0.00006993665,0.00006014256,0.000004522201,0.000002879432,0.00001736083,0.9822083,0.001474633,0.000297036,0.002114662],"study_design_scores_gemma":[0.0003343156,0.0001558465,0.008415607,0.00004359043,0.00001017037,0.000001007758,0.0000272644,0.00004743843,0.9901727,0.0004126057,0.0002838181,0.0000956428],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9906448,0.0004437434,0.004836248,0.00007584693,0.00005784841,0.0001671249,0.00003049965,0.000008517079,0.003735422],"genre_scores_gemma":[0.9965383,0.00006216321,0.0001882155,0.00005872403,0.00007761259,0.00001852459,0.00003597575,0.000010486,0.003009963],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.007964378,"threshold_uncertainty_score":0.3982845,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01806900128769877,"score_gpt":0.3131712194572122,"score_spread":0.2951022181695134,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}