{"id":"W4409226545","doi":"10.1212/wnl.0000000000211299","title":"Neither Food nor the Use of Sprinkle Delivery Impacts the Oral Bioavailability (BA) of a Novel Extended-Release (XR) Formulation of Lacosamide (P9-9.002)","year":2025,"lang":"en","type":"article","venue":"Neurology","topic":"Advanced Drug Delivery Systems","field":"Pharmacology, Toxicology and Pharmaceutics","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Aurinia (Canada)","funders":"","keywords":"Lacosamide; Bioavailability; Immediate release; Pharmacology; Medicine; Psychiatry; Epilepsy","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001931007,0.0002286324,0.0002505147,0.0000686769,0.00009174334,0.0002886689,0.0001508735,0.0001666235,0.001196102],"category_scores_gemma":[0.00044535,0.00006646969,0.0001260892,0.00008342194,0.0002504849,0.0003832028,0.0001348043,0.0003943789,0.0001795593],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001697437,"about_ca_system_score_gemma":0.000242062,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006516839,"about_ca_topic_score_gemma":0.0009862859,"domain_scores_codex":[0.9998652,0.0000279143,0.00001081449,0.00004154422,0.00003891542,0.00001565861],"domain_scores_gemma":[0.9998166,0.00005352765,0.00007577784,0.00001417767,0.00001764646,0.00002224843],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.003899641,0.0002936206,0.0008686338,0.0002481169,0.00002674444,0.0001017952,0.00004584705,0.00009838978,0.977732,0.00008670471,0.00008271316,0.01651576],"study_design_scores_gemma":[0.0001467843,0.0204821,0.01232432,0.00002824656,0.0001038539,0.0004353456,0.00008666725,0.0009887026,0.960012,0.0000557731,0.005312482,0.00002374316],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9966732,0.001252645,0.001119439,0.00004762365,0.00003397269,0.0000349629,0.0001255662,0.00002330466,0.000689225],"genre_scores_gemma":[0.9949837,0.001000827,0.002144891,0.00004744504,0.00001196734,0.00002753652,0.0001260241,0.00001189026,0.001645784],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001196102,"threshold_uncertainty_score":0.004001379,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1548496466944318,"score_gpt":0.3955276821932979,"score_spread":0.2406780354988661,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}