{"id":"W4409227100","doi":"10.1212/wnl.0000000000212224","title":"The Phase 3 PROOF-HD Trial Demonstrates Meaningful Benefits of Pridopidine on Function, Cognition, and Motor Signs in Huntington Disease (HD) (PL5.002)","year":2025,"lang":"en","type":"article","venue":"Neurology","topic":"Genetic Neurodegenerative Diseases","field":"Neuroscience","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia","funders":"","keywords":"Cognition; Disease; Huntington's disease; Motor function; Psychology; Medicine; Physical medicine and rehabilitation; Neuroscience; Internal medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001298661,0.001035378,0.001316736,0.0002137866,0.000421869,0.0007684291,0.0007104703,0.001645218,0.008064562],"category_scores_gemma":[0.001681757,0.0002773775,0.001412309,0.0001607698,0.0004857282,0.0008101395,0.0002867258,0.003221048,0.00143787],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005273593,"about_ca_system_score_gemma":0.0007561701,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001188784,"about_ca_topic_score_gemma":0.004942172,"domain_scores_codex":[0.9997464,0.0001301711,0.00001474713,0.00003716454,0.00002829671,0.00004326749],"domain_scores_gemma":[0.9991794,0.0002514381,0.0001530374,0.00005560326,0.00008175231,0.0002787374],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.8246334,0.009262661,0.004154986,0.002332369,0.003031908,0.0002261128,0.0001719744,0.0006068904,0.0148846,0.0006445204,0.01398022,0.1260704],"study_design_scores_gemma":[0.8384584,0.1286956,0.02239756,0.000201496,0.001160482,0.0003195767,0.00006259683,0.0006747287,0.002240756,0.0006523069,0.005088976,0.0000474365],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9638958,0.01312133,0.001664096,0.002261935,0.0006251338,0.002549222,0.006355681,0.0004915476,0.009035276],"genre_scores_gemma":[0.9795415,0.003636712,0.003266982,0.003095916,0.0003994712,0.001305188,0.004673607,0.00006618672,0.004014482],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.008064562,"threshold_uncertainty_score":0.02697867,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02690621792761678,"score_gpt":0.2788485376153361,"score_spread":0.2519423196877194,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}