{"id":"W4409229126","doi":"10.1093/brain/awaf118","title":"Mitochondrial damage is associated with an early immune response in inclusion body myositis","year":2025,"lang":"en","type":"article","venue":"Brain","topic":"Inflammatory Myopathies and Dermatomyositis","field":"Medicine","cited_by":17,"is_retracted":false,"has_abstract":true,"ca_institutions":"Children's Hospital of Eastern Ontario","funders":"Stoneygate Trust; Medical Research Council; National Institutes of Health; Muscular Dystrophy UK; Lily Foundation; Evelyn Trust; NIHR Cambridge Biomedical Research Centre; European Regional Development Fund; European Commission; Deutsche Gesellschaft für Muskelkranke; Addenbrooke's Charitable Trust, Cambridge University Hospitals; Ataxia UK; National Institute for Health and Care Research; Department of Health and Social Care; Wellcome Trust","keywords":"Mitochondrial DNA; Inclusion body myositis; Biology; Mitochondrial myopathy; Genetics; Mitochondrion; Molecular biology; Polymyositis; Pathology; Immunology; Gene; Medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003040321,0.0003130981,0.0003773153,0.0009887984,0.000301568,0.0002854777,0.0001404079,0.00038962,0.001034051],"category_scores_gemma":[0.0008697859,0.0002052529,0.0001821233,0.0004582271,0.0004168098,0.0002999951,0.0003455828,0.0003080451,0.000188001],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001463911,"about_ca_system_score_gemma":0.00006154616,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002530169,"about_ca_topic_score_gemma":0.0002627501,"domain_scores_codex":[0.9998211,0.00004260198,0.0000226298,0.00004345914,0.00004161531,0.00002862383],"domain_scores_gemma":[0.9994954,0.0001074408,0.000214014,0.00002966869,0.00006983992,0.00008370806],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.00157779,0.0001436416,0.8741227,0.0001724138,0.0001038864,0.009574511,0.0006495069,0.000161103,0.1032004,0.0001041903,0.0001282931,0.01006163],"study_design_scores_gemma":[0.0000160058,0.0004077579,0.9835724,0.00001159725,0.00003182526,0.01297839,0.0002326594,0.0001396892,0.002300726,0.00006502435,0.0002394626,0.00000450427],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9993174,0.0003456197,0.0001405856,0.0000128062,0.000002568127,0.000004541662,0.00001735071,0.000003886416,0.0001552372],"genre_scores_gemma":[0.9996845,0.0001040558,0.00008047549,0.00001127156,0.000007547721,0.00000321909,0.00003243804,0.000001566719,0.00007506493],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001034051,"threshold_uncertainty_score":0.003459275,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.005095583449271648,"score_gpt":0.2555687553562445,"score_spread":0.2504731719069729,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}