{"id":"W4409229126","doi":"10.1093/brain/awaf118","title":"Mitochondrial damage is associated with an early immune response in inclusion body myositis","year":2025,"lang":"en","type":"article","venue":"Brain","topic":"Inflammatory Myopathies and Dermatomyositis","field":"Medicine","cited_by":17,"is_retracted":false,"has_abstract":true,"ca_institutions":"Children's Hospital of Eastern Ontario","funders":"Stoneygate Trust; Medical Research Council; National Institutes of Health; Muscular Dystrophy UK; Lily Foundation; Evelyn Trust; NIHR Cambridge Biomedical Research Centre; European Regional Development Fund; European Commission; Deutsche Gesellschaft für Muskelkranke; Addenbrooke's Charitable Trust, Cambridge University Hospitals; Ataxia UK; National Institute for Health and Care Research; Department of Health and Social Care; Wellcome Trust","keywords":"Mitochondrial DNA; Inclusion body myositis; Biology; Mitochondrial myopathy; Genetics; Mitochondrion; Molecular biology; Polymyositis; Pathology; Immunology; Gene; Medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005575022,0.0001791442,0.0003731267,0.0003171795,0.0002464681,0.00004320513,0.0001342906,0.0001958059,0.0001035999],"category_scores_gemma":[0.0004365644,0.0001601374,0.00006711508,0.0005253016,0.00007655556,0.0001777846,0.0002260317,0.0002985835,0.00002070932],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001784207,"about_ca_system_score_gemma":0.0002534107,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002923811,"about_ca_topic_score_gemma":0.00009334023,"domain_scores_codex":[0.9983472,0.0003813476,0.0003543349,0.000296274,0.000302868,0.0003180031],"domain_scores_gemma":[0.9990457,0.0002440054,0.0000865713,0.0004261602,0.00009811479,0.00009942571],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.07165213,0.001302987,0.07674512,0.0002121386,0.0003565702,0.01317626,0.023483,0.00001193811,0.7693414,0.002038629,0.03684068,0.004839109],"study_design_scores_gemma":[0.008181318,0.001213299,0.9715682,0.0009462736,0.00004910483,0.000048711,0.0002619904,0.000556628,0.01080632,0.0002432608,0.005876135,0.0002487386],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9898441,0.00009859805,0.00008887478,0.007078259,0.0001829761,0.0004752035,0.00002532739,0.0001059865,0.002100633],"genre_scores_gemma":[0.9901952,0.000004474971,0.0002895122,0.004372377,0.00007643377,0.00002906997,0.00006408288,0.00002772227,0.004941095],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.8948231,"threshold_uncertainty_score":0.6530213,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.005095583449271648,"score_gpt":0.2555687553562445,"score_spread":0.2504731719069729,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}