{"id":"W4409229252","doi":"10.1002/chem.202500994","title":"Immunological and Toxicological Assessment of Triterpenoid Saponins Bearing Lewis‐X‐ and QS‐21‐Based Trisaccharides","year":2025,"lang":"en","type":"article","venue":"Chemistry - A European Journal","topic":"Natural product bioactivities and synthesis","field":"Biochemistry, Genetics and Molecular Biology","cited_by":2,"is_retracted":false,"has_abstract":true,"ca_institutions":"Institut National de la Recherche Scientifique; Université du Québec à Chicoutimi","funders":"Fondation Jean-Louis Lévesque; Natural Sciences and Engineering Research Council of Canada; Amsterdam University Medical Centers; Fonds de Recherche du Québec - Santé; Fonds de recherche du Québec – Nature et technologies; Armand-Frappier Foundation","keywords":"Chemistry; Oleanolic acid; Betulinic acid; Triterpenoid saponin; Saponin; Lithocholic acid; Stereochemistry; Ovalbumin; Glycosylation; Biochemistry; Antigen; Biology; Immunology; Bile acid","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001893451,0.0002751692,0.0001001379,0.0001588628,0.00005796897,0.0001379449,0.0001035168,0.0001855315,0.0004009087],"category_scores_gemma":[0.0001018324,0.00004371365,0.0001089158,0.00008288132,0.0001594659,0.0001274001,0.00008440192,0.0002201523,0.0001121351],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001501502,"about_ca_system_score_gemma":0.0001137488,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002176156,"about_ca_topic_score_gemma":0.00026581,"domain_scores_codex":[0.9999332,0.00001991815,0.000005388678,0.000008755351,0.0000189172,0.0000137282],"domain_scores_gemma":[0.9999123,0.00001766071,0.00002357209,0.000007881128,0.00001567191,0.00002291795],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00004327026,0.00001513704,0.00006576843,0.00001198808,0.000001434654,0.00001442801,0.000005121472,0.00007246785,0.9993777,0.0000197134,0.000002657737,0.0003704288],"study_design_scores_gemma":[0.000004704164,0.0005485613,0.001161414,0.000001489676,0.000007996056,0.00005901494,0.000008345055,0.0002809526,0.997644,0.00001599453,0.0002654304,0.000002021827],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9983027,0.0003731528,0.0008449495,0.00001153012,0.000003791328,0.00001292458,0.00005479655,0.000008935963,0.0003872715],"genre_scores_gemma":[0.9975321,0.0005195531,0.001127323,0.0000162668,0.000003650846,0.00001144823,0.0001442492,0.000003817492,0.0006414973],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0004009087,"threshold_uncertainty_score":0.001341164,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01115065100275615,"score_gpt":0.2621249776984513,"score_spread":0.2509743266956952,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}