{"id":"W4409234657","doi":"10.1212/wnl.0000000000209086","title":"Phase 3, Open-Label, Safety Extension Study of Oral Edaravone (Radicava ORS®) Administered Over 96 Weeks in Patients with ALS (MT-1186-A03) (S27.007)","year":2025,"lang":"nl","type":"article","venue":"Neurology","topic":"Cerebral Palsy and Movement Disorders","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Montreal Neurological Institute and Hospital","funders":"","keywords":"Edaravone; Medicine; Open label; Extension (predicate logic); Anesthesia; Internal medicine; Audiology; Adverse effect; Computer science; Programming language","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001335843,0.001742429,0.002574207,0.0004061712,0.0005109403,0.000968119,0.001108239,0.001495708,0.005216504],"category_scores_gemma":[0.0008890188,0.0007673826,0.00206332,0.0003980713,0.001241145,0.001013732,0.000308448,0.003888711,0.00136255],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0007486349,"about_ca_system_score_gemma":0.001973993,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001536238,"about_ca_topic_score_gemma":0.00296339,"domain_scores_codex":[0.9996153,0.0001511902,0.00001840916,0.00008427627,0.00003674854,0.00009419683],"domain_scores_gemma":[0.9991615,0.0001463051,0.0001576007,0.00009169571,0.00007820176,0.0003646651],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"nonrandomized_trial","study_design_scores_codex":[0.8779728,0.04699094,0.001369941,0.0005983691,0.001124438,0.000154249,0.0002065503,0.001023143,0.03301266,0.0001818728,0.001981549,0.03538354],"study_design_scores_gemma":[0.6261605,0.36294,0.005216744,0.00002934122,0.0005014681,0.0001444884,0.00005722903,0.0007074817,0.002461925,0.0001525895,0.001597035,0.00003124861],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9918067,0.002046853,0.0008447284,0.0002838282,0.0002015132,0.002194318,0.001180045,0.0001382858,0.001303799],"genre_scores_gemma":[0.9870863,0.001800056,0.001819454,0.0007279104,0.0002099792,0.003108411,0.001850024,0.0000467436,0.00335111],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.005216504,"threshold_uncertainty_score":0.01745099,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02970092474949817,"score_gpt":0.3371623340911825,"score_spread":0.3074614093416843,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}