{"id":"W4409237257","doi":"10.1212/wnl.0000000000211988","title":"Pridopidine for the Treatment of ALS–Improvements in the Subgroup of Definite, Probable, and Early (&lt;18mo from Onset) Subjects in the Phase 2 Healey ALS Platform Trial (S5.010)","year":2025,"lang":"en","type":"article","venue":"Neurology","topic":"Amyotrophic Lateral Sclerosis Research","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia","funders":"","keywords":"Subgroup analysis; Medicine; Pediatrics; Psychology; Internal medicine; Confidence interval","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00112134,0.0008235674,0.001370149,0.0001625954,0.0003002254,0.0004904502,0.0003431132,0.0006327022,0.002862035],"category_scores_gemma":[0.0006797707,0.0002028401,0.001004165,0.0001686251,0.0002382592,0.0003961409,0.0002002316,0.001352185,0.0003199104],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003549779,"about_ca_system_score_gemma":0.0005513666,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001267407,"about_ca_topic_score_gemma":0.006907723,"domain_scores_codex":[0.9997278,0.0001480701,0.00001286727,0.00004404512,0.00002164049,0.00004550524],"domain_scores_gemma":[0.999729,0.00006114333,0.00006275246,0.00001925649,0.00002368205,0.0001041356],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"nonrandomized_trial","study_design_scores_codex":[0.9236843,0.002062841,0.005554637,0.00109905,0.002596331,0.000140255,0.0001044901,0.0003977051,0.00830646,0.0002406975,0.003595737,0.05221745],"study_design_scores_gemma":[0.7607338,0.1503357,0.07649899,0.0002942279,0.003306244,0.0003773807,0.000120339,0.001458314,0.001624042,0.0007031394,0.00449763,0.00005026474],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9859503,0.008411098,0.0002473431,0.0005144505,0.0002072123,0.0004354728,0.001216896,0.00005010662,0.00296717],"genre_scores_gemma":[0.9927995,0.002714185,0.0005295197,0.0004756199,0.0002259882,0.0003005767,0.001184853,0.00001134036,0.001758386],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002862035,"threshold_uncertainty_score":0.009574473,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.06068370439599909,"score_gpt":0.3492533192869465,"score_spread":0.2885696148909475,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}