{"id":"W4409245927","doi":"10.1111/apha.70043","title":"Cav3.1 T‐Type Calcium Channel Acts as a Gateway for <scp>GABAergic</scp> Excitation in the Medial Prefrontal Cortex That Leads to Chronic Psychological Stress Responses in Mice","year":2025,"lang":"en","type":"article","venue":"Acta Physiologica","topic":"Neurotransmitter Receptor Influence on Behavior","field":"Neuroscience","cited_by":5,"is_retracted":false,"has_abstract":true,"ca_institutions":"Alberta Children's Hospital; University of Calgary","funders":"Japan Society for the Promotion of Science; Takeda Science Foundation","keywords":"GABAergic; Optogenetics; Prefrontal cortex; Parvalbumin; Neuroscience; Calcium channel; Chronic stress; Excitatory postsynaptic potential; Voltage-dependent calcium channel; Behavioural despair test; Electrophysiology; Biology; Inhibitory postsynaptic potential; Medicine; Internal medicine; Hippocampus; Antidepressant; Calcium","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001717676,0.000477119,0.0003365526,0.0004064499,0.0003451426,0.0004446653,0.0004624169,0.0006356018,0.002187663],"category_scores_gemma":[0.0001359506,0.0002819574,0.0005876365,0.0001728227,0.0007146322,0.000400671,0.0003192343,0.001791304,0.0004305549],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006020388,"about_ca_system_score_gemma":0.0005691911,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002237352,"about_ca_topic_score_gemma":0.003529632,"domain_scores_codex":[0.9997372,0.00001903796,0.00002397438,0.00008989266,0.00005372591,0.0000761881],"domain_scores_gemma":[0.9996735,0.00001816932,0.0001621383,0.00002308474,0.00003017913,0.00009298379],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002056879,0.00002139118,0.0002708508,0.00003179138,0.000008027211,0.0000810476,0.00001488139,0.00003932906,0.9985527,0.000115302,0.00007129585,0.0005877772],"study_design_scores_gemma":[0.0002413455,0.0007770672,0.0290479,0.00005660511,0.0001210256,0.001285165,0.0002235387,0.003327608,0.9603415,0.0005812931,0.003963193,0.0000338716],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9899163,0.0005959838,0.006009613,0.0005503398,0.00009758727,0.00004382458,0.001327483,0.000346579,0.001112387],"genre_scores_gemma":[0.9917203,0.0006206366,0.003484597,0.000332387,0.00002830483,0.0001116685,0.0006891554,0.0001808267,0.002832291],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002237352,"threshold_uncertainty_score":0.007318497,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.08167892480452103,"score_gpt":0.3705383166860838,"score_spread":0.2888593918815627,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}