{"id":"W4409247738","doi":"10.1056/nejmoa2415988","title":"Tolebrutinib in Nonrelapsing Secondary Progressive Multiple Sclerosis","year":2025,"lang":"en","type":"article","venue":"New England Journal of Medicine","topic":"Multiple Sclerosis Research Studies","field":"Medicine","cited_by":111,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia","funders":"Sanofi","keywords":"Multiple sclerosis; Medicine; Psychiatry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001544344,0.0001979013,0.0008432036,0.0007539713,0.00007565234,0.00001443506,0.000180004,0.00009057263,0.0002940104],"category_scores_gemma":[0.004978869,0.0001295586,0.0001086761,0.0006063777,0.0002486052,0.0001219416,0.00008230434,0.0009474849,0.000003810337],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001660586,"about_ca_system_score_gemma":0.0005884626,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001428394,"about_ca_topic_score_gemma":0.0001200416,"domain_scores_codex":[0.9977208,0.0001584344,0.0008713534,0.0002007636,0.0006719944,0.0003765907],"domain_scores_gemma":[0.9978915,0.0008848257,0.0002857035,0.0002178028,0.0004096023,0.0003105494],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"observational","study_design_scores_codex":[0.003030309,0.0002546533,0.1403078,0.000248311,0.0003305922,0.0005992402,0.00214575,0.00002389029,0.02571847,0.00004989274,0.05325786,0.7740332],"study_design_scores_gemma":[0.1974008,0.002140861,0.6942685,0.01278611,0.0002429197,0.0004883403,0.001685227,0.0003926177,0.004690232,0.0003119654,0.08538955,0.0002029681],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9070157,0.02041044,0.0006026599,0.05487835,0.001379265,0.0007148282,0.000004455311,0.00003118695,0.01496313],"genre_scores_gemma":[0.9924498,0.001747751,0.001852053,0.0009996211,0.001818831,0.000005545599,0.000004285514,0.00001628943,0.001105783],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.7738302,"threshold_uncertainty_score":0.5960531,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05695670069260519,"score_gpt":0.3363802458565232,"score_spread":0.279423545163918,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}