{"id":"W4409247738","doi":"10.1056/nejmoa2415988","title":"Tolebrutinib in Nonrelapsing Secondary Progressive Multiple Sclerosis","year":2025,"lang":"en","type":"article","venue":"New England Journal of Medicine","topic":"Multiple Sclerosis Research Studies","field":"Medicine","cited_by":111,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia","funders":"Sanofi","keywords":"Multiple sclerosis; Medicine; Psychiatry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001688396,0.0004221973,0.001328876,0.0002432776,0.0001603752,0.0003786939,0.000400668,0.0005392329,0.002634096],"category_scores_gemma":[0.001625064,0.0001213326,0.0006378228,0.0002786764,0.0003544597,0.0002681419,0.000210787,0.0008742835,0.0002275232],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00033437,"about_ca_system_score_gemma":0.0004058851,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003454554,"about_ca_topic_score_gemma":0.0009244359,"domain_scores_codex":[0.9993852,0.000378569,0.00004677872,0.00006011698,0.00006989446,0.00005927952],"domain_scores_gemma":[0.9992799,0.0003106479,0.0002133108,0.00003096516,0.00003675945,0.0001282747],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.6573352,0.004058015,0.008880747,0.004894852,0.00189599,0.0003820651,0.000140635,0.001845528,0.009496472,0.0005072615,0.003286854,0.3072762],"study_design_scores_gemma":[0.736531,0.1901295,0.05420872,0.0006388024,0.002388918,0.001083603,0.0001071781,0.003044005,0.002936877,0.001454398,0.007442824,0.00003420929],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.937367,0.05662358,0.0006527025,0.0009423976,0.0003266154,0.0005760489,0.0002793687,0.00008382916,0.003148453],"genre_scores_gemma":[0.9910746,0.007154631,0.0002879548,0.0004031083,0.0001674962,0.0002448756,0.0001785921,0.000004573265,0.000484107],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002634096,"threshold_uncertainty_score":0.008929193,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05695670069260519,"score_gpt":0.3363802458565232,"score_spread":0.279423545163918,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}