{"id":"W4409247771","doi":"10.1016/j.carbpol.2025.123581","title":"Chitosan nanovectors for siRNA delivery: New horizons for nonviral gene therapy","year":2025,"lang":"en","type":"review","venue":"Carbohydrate Polymers","topic":"RNA Interference and Gene Delivery","field":"Biochemistry, Genetics and Molecular Biology","cited_by":16,"is_retracted":false,"has_abstract":false,"ca_institutions":"Université de Montréal; Hôpital du Sacré-Cœur de Montréal","funders":"Canadian Institutes of Health Research; Ministère de l'Économie, de l’Innovation et des Exportations du Québec","keywords":"Chitosan; Gene delivery; Genetic enhancement; Chemistry; Delivery system; Nanotechnology; Gene; Biology; Materials science; Biochemistry; Pharmacology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0006253059,0.000994207,0.0009572141,0.001495762,0.0002052081,0.001093964,0.0008980844,0.001125377,0.003090705],"category_scores_gemma":[0.0004131979,0.0002797148,0.0003443043,0.001611875,0.0005078079,0.001164485,0.0005911401,0.00193091,0.001848159],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0009032256,"about_ca_system_score_gemma":0.001046319,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001529923,"about_ca_topic_score_gemma":0.003313759,"domain_scores_codex":[0.9998665,0.0000168208,0.00001001008,0.00001807547,0.00006832152,0.00002034132],"domain_scores_gemma":[0.999849,0.00006566705,0.00001875758,0.000005241166,0.00004067131,0.0000207919],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0001330684,0.0001190399,0.00007201089,0.01018917,0.00006291434,0.0002230522,0.00004234893,0.0004355793,0.01248579,0.008046062,0.03624374,0.9319472],"study_design_scores_gemma":[0.0000323604,0.000106051,0.0002919855,0.001241803,0.00006600771,0.0005451425,0.00002660322,0.0001602673,0.003328546,0.001660567,0.9925162,0.00002444716],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0001781112,0.9973296,0.0004424458,0.0002776287,0.0003182709,0.00000657514,0.00002063243,0.00001157534,0.001415195],"genre_scores_gemma":[0.0008734964,0.996901,0.000415498,0.000213361,0.0001311325,0.00000961771,0.00003480765,0.000002558629,0.001418487],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.003090705,"threshold_uncertainty_score":0.01033944,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02909800433596149,"score_gpt":0.3031074273790093,"score_spread":0.2740094230430478,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}