{"id":"W4409251014","doi":"10.1016/j.tmrv.2025.150897","title":"Identifying Modifiers of CAR T-Cell Therapeutic Efficacy and Safety: A Systematic Review and Individual Patient Data Meta-Analysis","year":2025,"lang":"en","type":"review","venue":"Transfusion Medicine Reviews","topic":"CAR-T cell therapy research","field":"Medicine","cited_by":4,"is_retracted":false,"has_abstract":true,"ca_institutions":"National Research Council Canada; Ottawa Public Health; University of Ottawa; University of British Columbia; Ottawa Hospital","funders":"Networks of Centres of Excellence of Canada; Copenhagen School of Energy Infrastructure; Canadian Institutes of Health Research","keywords":"Meta-analysis; Medicine; Internal medicine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.01792647,0.002622889,0.01905111,0.004968583,0.000551961,0.003216606,0.002113538,0.00241249,0.003879889],"category_scores_gemma":[0.03854841,0.001555326,0.04593492,0.00618355,0.0008385864,0.001644248,0.001547026,0.00210516,0.0003705242],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.002300763,"about_ca_system_score_gemma":0.002892971,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.006089455,"about_ca_topic_score_gemma":0.01043795,"domain_scores_codex":[0.9878149,0.006629235,0.003089317,0.001230759,0.000908445,0.0003272998],"domain_scores_gemma":[0.969049,0.02497235,0.003470198,0.0009585391,0.001284747,0.0002651852],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"meta_analysis","study_design_gemma":"meta_analysis","study_design_scores_codex":[0.001848077,0.00001967975,0.003003142,0.196613,0.7900565,0.000083399,0.00004781763,0.0005509247,0.0001599853,0.000119545,0.0003908857,0.007107039],"study_design_scores_gemma":[0.0004223445,0.0001097322,0.00175889,0.008705138,0.9876848,0.00004226682,0.00001813484,0.0001551356,0.0000679533,0.0001671378,0.0008551273,0.00001333625],"study_design_candidate":"meta_analysis","study_design_consensus":"meta_analysis","genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.006597856,0.9904475,0.001113483,0.0002470843,0.0001501177,0.000305576,0.000783378,0.00003993697,0.0003150515],"genre_scores_gemma":[0.3334233,0.6559287,0.004461459,0.001483753,0.0003476135,0.00202733,0.001683742,0.00008057071,0.0005635309],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.01905111,"threshold_uncertainty_score":0.09480536,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.347441955287403,"score_gpt":0.4512098839360388,"score_spread":0.1037679286486358,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}