{"id":"W4409252004","doi":"10.1136/jitc-2024-011049","title":"Consensus disease definitions for ophthalmic immune-related adverse events of immune checkpoint inhibitors","year":2025,"lang":"en","type":"article","venue":"Journal for ImmunoTherapy of Cancer","topic":"Cancer Immunotherapy and Biomarkers","field":"Medicine","cited_by":16,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Calgary","funders":"Project Data Sphere","keywords":"Medicine; Uveitis; Delphi method; Adverse effect; Family medicine; Disease; Usability; Ophthalmology; Internal medicine; Artificial intelligence; Computer science","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0007336498,0.0002859204,0.0007850219,0.0004157649,0.0002444327,0.000008123684,0.0002154853,0.0001595486,0.0003365681],"category_scores_gemma":[0.0001371654,0.0002465636,0.001773732,0.0004118253,0.0002648339,0.00008094838,0.00002009586,0.0002547786,8.719715e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003343928,"about_ca_system_score_gemma":0.001203037,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001678284,"about_ca_topic_score_gemma":0.000006586546,"domain_scores_codex":[0.9971182,0.00005323164,0.001935053,0.0002317533,0.0002962163,0.000365487],"domain_scores_gemma":[0.9974447,0.0002326816,0.001149679,0.0003955624,0.0006749346,0.0001023743],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.06341969,0.000959314,0.006196389,0.001098337,0.005463091,0.000006646085,0.0004838584,0.0001582497,0.8899759,0.0005831886,0.001567713,0.03008762],"study_design_scores_gemma":[0.09795777,0.003629743,0.2097496,0.01123831,0.002529563,0.0002149725,0.001356162,0.0004805392,0.5955756,0.01484146,0.06138962,0.001036687],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9174752,0.07263742,0.0005043221,0.003519794,0.002960762,0.002047401,0.0004665713,0.00002958429,0.00035901],"genre_scores_gemma":[0.9846264,0.0102765,0.001296646,0.0002784912,0.0001218771,0.0003002786,0.00004943107,0.0000681942,0.002982201],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2944004,"threshold_uncertainty_score":0.9999987,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02507272628711672,"score_gpt":0.3355969537691115,"score_spread":0.3105242274819948,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}