{"id":"W4409252656","doi":"10.1053/j.seminhematol.2025.04.004","title":"Report of Consensus Panel 5 from the 12th International Workshop on Waldenstrom's Macroglobulinemia on the management of patients with intolerance or resistance to covalent BTK inhibitors","year":2025,"lang":"en","type":"article","venue":"Seminars in Hematology","topic":"Chronic Lymphocytic Leukemia Research","field":"Medicine","cited_by":4,"is_retracted":false,"has_abstract":true,"ca_institutions":"Sunnybrook Health Science Centre","funders":"Pharmacyclics; BeiGene; Eli Lilly and Company","keywords":"Waldenstrom macroglobulinemia; Medicine; Macroglobulinemia; Ibrutinib; Bruton's tyrosine kinase; Intensive care medicine; Internal medicine; Immunology; Lymphoma; Chronic lymphocytic leukemia; Leukemia; Multiple myeloma","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003890453,0.0001703819,0.0004271871,0.0001242764,0.00003812854,0.000005873183,0.0003718485,0.00009807041,0.00008400834],"category_scores_gemma":[0.0005441193,0.00009152791,0.00005426492,0.0004716164,0.0003528147,0.000009005875,0.0001995831,0.0002786325,0.000006155268],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001593758,"about_ca_system_score_gemma":0.0006767088,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00009746345,"about_ca_topic_score_gemma":0.0001982054,"domain_scores_codex":[0.9979769,0.0000833828,0.000653811,0.0004038899,0.0006229973,0.0002590469],"domain_scores_gemma":[0.9972804,0.001418441,0.0002381819,0.0008258171,0.0001917374,0.00004540864],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.1083988,0.004457259,0.4956329,0.003146787,0.00355508,0.02024121,0.004588503,0.001589542,0.0003833004,0.05186607,0.2839296,0.02221096],"study_design_scores_gemma":[0.1226504,0.003895586,0.4097458,0.167169,0.001175237,0.001501338,0.02001893,0.003655354,0.1822006,0.006057299,0.08006229,0.001868072],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9843833,0.0002324605,0.0000472941,0.009894525,0.0003225975,0.001064199,0.00003478192,0.00001168743,0.004009091],"genre_scores_gemma":[0.9957258,0.00008346359,0.001167341,0.0006639001,0.00002259556,0.00009493663,0.00002905943,0.00001436995,0.002198547],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2038673,"threshold_uncertainty_score":0.4167623,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02067908678759185,"score_gpt":0.3092122550952038,"score_spread":0.2885331683076119,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}