{"id":"W4409260804","doi":"10.1016/j.cllc.2025.04.001","title":"Real-World Creatinine-Based Estimates of Acute and Chronic Kidney Dysfunction in Patients with Advanced ALK-Rearranged Non-Small-Cell Lung Cancer Receiving Tyrosine Kinase Inhibitors","year":2025,"lang":"en","type":"article","venue":"Clinical Lung Cancer","topic":"Chemotherapy-induced organ toxicity mitigation","field":"Medicine","cited_by":2,"is_retracted":false,"has_abstract":false,"ca_institutions":"Princess Margaret Cancer Centre; University of Toronto; Takeda (Canada); Centre Hospitalier de l’Université de Montréal; University Health Network","funders":"University Health Network","keywords":"Medicine; Lung cancer; Creatinine; Internal medicine; Tyrosine kinase; Oncology; Lung; Anaplastic lymphoma kinase; Cancer; Crizotinib; Cancer research; Receptor","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0003039177,0.0003070385,0.000748163,0.0002643669,0.00007075463,0.00001863405,0.00009161875,0.000210915,0.0001376723],"category_scores_gemma":[0.0002446777,0.0002682242,0.00009987754,0.000817935,0.000186003,0.0001489164,0.00004143945,0.0004821116,6.701421e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0008827922,"about_ca_system_score_gemma":0.001253432,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007414753,"about_ca_topic_score_gemma":0.001444994,"domain_scores_codex":[0.9978436,0.000071681,0.0008634397,0.0006163434,0.000268826,0.0003361656],"domain_scores_gemma":[0.9983513,0.0003504487,0.0004075307,0.0003807222,0.0002839317,0.000226011],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.002249605,0.0004028799,0.9378207,0.001065849,0.0002342614,0.000004126546,0.00009537519,0.000192942,0.04325731,0.000002190099,0.001444646,0.01323008],"study_design_scores_gemma":[0.01945945,0.0006038966,0.7766519,0.00680125,0.0008358009,1.574826e-7,0.00001135242,0.00773509,0.1875344,0.000005802993,0.00009838302,0.0002624797],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9947413,0.0007998404,0.0002272682,0.001637806,0.0004723403,0.00147066,0.00006462919,0.00006913497,0.0005169793],"genre_scores_gemma":[0.9953477,0.0008703811,0.001786295,0.0009400796,0.0002082509,0.0001901485,0.0001321623,0.00006504929,0.0004599563],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1611688,"threshold_uncertainty_score":0.999977,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.009388244117177437,"score_gpt":0.3259740877169874,"score_spread":0.31658584359981,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}