{"id":"W4409264039","doi":"10.1182/bloodadvances.2025015862","title":"Agents of shield: glycans mask antibody epitopes on ADAMTS13","year":2025,"lang":"en","type":"letter","venue":"Blood Advances","topic":"Complement system in diseases","field":"Immunology and Microbiology","cited_by":0,"is_retracted":false,"has_abstract":false,"ca_institutions":"McMaster University; Thrombosis and Atherosclerosis Research Institute","funders":"","keywords":"Epitope; Glycan; Antibody; Molecular biology; Chemistry; Computational biology; Virology; Biology; Immunology; Glycoprotein","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.00008890971,0.0004286456,0.0007920228,0.0002857767,0.0001161971,0.000014174,0.0007496055,0.0005203211,0.001685057],"category_scores_gemma":[0.0001016374,0.0003799698,0.0002729408,0.0001600529,0.0001901917,0.00007880172,0.0001740566,0.0006956831,0.0002309892],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002173944,"about_ca_system_score_gemma":0.0001116324,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00007567772,"about_ca_topic_score_gemma":0.00002330493,"domain_scores_codex":[0.9979011,0.0002877711,0.0006105332,0.0006051656,0.000115423,0.0004799668],"domain_scores_gemma":[0.9982466,0.0005062279,0.000443333,0.000724239,0.00006495007,0.0000147244],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"not_applicable","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00007940283,0.0002775848,0.004036732,0.001074052,0.0009469663,0.0001085358,0.00007011602,0.000007057421,0.003476416,0.0001927416,0.9874556,0.002274771],"study_design_scores_gemma":[0.0009789828,0.0002614658,0.000850171,0.001112065,0.000395954,0.00001411818,0.00007855366,1.095063e-7,0.01149144,0.0002043008,0.984278,0.0003348672],"study_design_candidate":"not_applicable","study_design_consensus":"not_applicable","genre_codex":"commentary","genre_gemma":"commentary","genre_scores_codex":[0.116494,0.2210523,0.0002072436,0.5017732,0.03533703,0.007136255,0.01846858,0.001172212,0.09835915],"genre_scores_gemma":[0.2968858,0.004792172,0.0003775016,0.5384169,0.003829388,0.0005574022,0.01652497,0.0002257088,0.1383901],"genre_candidate":"commentary","genre_consensus":"commentary","teacher_disagreement_score":0.2162601,"threshold_uncertainty_score":0.9998652,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01557758826554697,"score_gpt":0.2984281988180642,"score_spread":0.2828506105525173,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}