{"id":"W4409264039","doi":"10.1182/bloodadvances.2025015862","title":"Agents of shield: glycans mask antibody epitopes on ADAMTS13","year":2025,"lang":"en","type":"letter","venue":"Blood Advances","topic":"Complement system in diseases","field":"Immunology and Microbiology","cited_by":0,"is_retracted":false,"has_abstract":false,"ca_institutions":"McMaster University; Thrombosis and Atherosclerosis Research Institute","funders":"","keywords":"Epitope; Glycan; Antibody; Molecular biology; Chemistry; Computational biology; Virology; Biology; Immunology; Glycoprotein","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001407047,0.0006498357,0.0005548159,0.0002431218,0.001023306,0.001266759,0.0006762749,0.01462846,0.002991341],"category_scores_gemma":[0.004597724,0.0003296951,0.0006536159,0.0001079721,0.001645124,0.001517831,0.0008011318,0.01084173,0.001659671],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001335175,"about_ca_system_score_gemma":0.0004458476,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006791276,"about_ca_topic_score_gemma":0.0008822826,"domain_scores_codex":[0.999374,0.0002241299,0.00004224704,0.00005052456,0.0002122017,0.00009688555],"domain_scores_gemma":[0.9989744,0.0007242186,0.00006797032,0.00005273837,0.00007270431,0.0001078856],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"not_applicable","study_design_gemma":"observational","study_design_scores_codex":[0.0005576327,0.000161583,0.000955658,0.0002329767,0.00009037609,0.02483881,0.0002245702,0.0003299869,0.008947405,0.02393754,0.9020011,0.03772224],"study_design_scores_gemma":[0.0006654682,0.0003890139,0.0009244662,0.0001428397,0.00006634476,0.0164156,0.0001517617,0.001473327,0.01069204,0.02693303,0.9421072,0.00003895003],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"commentary","genre_gemma":"empirical","genre_scores_codex":[0.01118478,0.01443307,0.00202681,0.9106441,0.03797635,0.0000621868,0.00006899844,0.0001626332,0.02344118],"genre_scores_gemma":[0.1981909,0.01142614,0.002737286,0.6427941,0.09874465,0.0001523656,0.00009079711,0.00008812275,0.04577569],"genre_candidate":"empirical","genre_consensus":null,"teacher_disagreement_score":0.01462846,"threshold_uncertainty_score":0.01000708,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01557758826554697,"score_gpt":0.2984281988180642,"score_spread":0.2828506105525173,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}