{"id":"W4409271389","doi":"10.3390/ijms26083456","title":"Recent Update on siRNA Therapeutics","year":2025,"lang":"en","type":"review","venue":"International Journal of Molecular Sciences","topic":"RNA Interference and Gene Delivery","field":"Biochemistry, Genetics and Molecular Biology","cited_by":34,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta","funders":"","keywords":"Small interfering RNA; Gene silencing; Mechanism (biology); Computational biology; Disease; RNA interference; Medicine; Bioinformatics; Biology; RNA; Gene; Genetics; Pathology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004325866,0.0002306278,0.0004243251,0.0003448955,0.0000457746,0.0001195738,0.001640649,0.0001692593,0.00002915682],"category_scores_gemma":[0.0001027279,0.0001659675,0.0004844235,0.0001787805,0.0001308964,0.000007446623,0.0001658488,0.0002207134,0.0000200806],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00004170668,"about_ca_system_score_gemma":0.0008242851,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":8.165725e-7,"about_ca_topic_score_gemma":0.00000110278,"domain_scores_codex":[0.9982635,0.0001345873,0.0005605936,0.0002783302,0.0006014712,0.0001614782],"domain_scores_gemma":[0.9986615,0.00003517476,0.0005851676,0.000189769,0.0004766402,0.00005177872],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00002337101,0.00005570561,0.000001448577,0.00007289011,0.0004346553,0.00006675099,0.000005047444,0.00004399886,0.0004451271,0.0001936232,0.001189389,0.997468],"study_design_scores_gemma":[0.0001202742,0.000387685,6.65368e-7,0.002416371,0.0001317225,0.0001374221,0.00001155263,0.000002177619,0.002558293,0.0001377517,0.9939362,0.000159923],"study_design_candidate":"design_other","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0003980395,0.9946502,0.0004923879,0.0003493932,0.001890928,0.00009016346,0.00002251392,0.000002406135,0.002103932],"genre_scores_gemma":[0.0003491157,0.9974263,0.0003124266,0.001312425,0.0003332448,0.000003645297,0.0000266996,0.00001082783,0.0002253161],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.9973081,"threshold_uncertainty_score":0.6767958,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04466292616957544,"score_gpt":0.3746947365576231,"score_spread":0.3300318103880476,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}