{"id":"W4409271389","doi":"10.3390/ijms26083456","title":"Recent Update on siRNA Therapeutics","year":2025,"lang":"en","type":"review","venue":"International Journal of Molecular Sciences","topic":"RNA Interference and Gene Delivery","field":"Biochemistry, Genetics and Molecular Biology","cited_by":34,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta","funders":"","keywords":"Small interfering RNA; Gene silencing; Mechanism (biology); Computational biology; Disease; RNA interference; Medicine; Bioinformatics; Biology; RNA; Gene; Genetics; Pathology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0006582594,0.001009785,0.00138708,0.002583196,0.0003391356,0.001417696,0.001182644,0.001601352,0.01571829],"category_scores_gemma":[0.001215113,0.0003268612,0.000709852,0.002035246,0.0003630366,0.001897799,0.0009364813,0.003008445,0.01132804],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000757176,"about_ca_system_score_gemma":0.001245532,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008432255,"about_ca_topic_score_gemma":0.001681115,"domain_scores_codex":[0.999693,0.00005001389,0.00005042977,0.00005186882,0.0001217481,0.00003289244],"domain_scores_gemma":[0.9994722,0.0002172178,0.00004932918,0.0000160544,0.0001742856,0.00007091009],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0001083379,0.00008696935,0.0001143129,0.01307414,0.00007154791,0.0003500392,0.00006525374,0.0002964704,0.002510129,0.004267182,0.1576264,0.8214291],"study_design_scores_gemma":[0.000009111193,0.00004445701,0.000115908,0.00107071,0.0000307692,0.0006389151,0.00001194099,0.00002953505,0.0002124499,0.0005087393,0.9973198,0.000007751833],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0001740005,0.9897538,0.0003605387,0.001263203,0.002816048,0.00001981247,0.0001154013,0.00004207175,0.00545506],"genre_scores_gemma":[0.0006835275,0.9902732,0.0005103165,0.001610158,0.001585059,0.00002980669,0.0002631268,0.000009979336,0.005034881],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.01571829,"threshold_uncertainty_score":0.05258286,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04466292616957544,"score_gpt":0.3746947365576231,"score_spread":0.3300318103880476,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}