{"id":"W4409276024","doi":"10.3389/fcell.2025.1559155","title":"Engineered mesenchymal stromal cells with interleukin-1beta sticky-trap attenuate osteoarthritis in knee joints","year":2025,"lang":"en","type":"article","venue":"Frontiers in Cell and Developmental Biology","topic":"Osteoarthritis Treatment and Mechanisms","field":"Medicine","cited_by":3,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto; Sinai Health System; Lunenfeld-Tanenbaum Research Institute; University Health Network","funders":"Canadian Institutes of Health Research; Canada Research Chairs; Ontario Research Foundation","keywords":"Mesenchymal stem cell; Osteoarthritis; Cell biology; Interleukin; Medicine; Stromal cell; Trap (plumbing); Immunology; Biology; Pathology; Cytokine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002586579,0.0007510282,0.0006801504,0.0003445655,0.0001304054,0.0004374493,0.000249243,0.0005452909,0.001377607],"category_scores_gemma":[0.0001098423,0.0002791896,0.0004525996,0.000251756,0.0004171354,0.00030284,0.0002594025,0.001127348,0.0003238033],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002386516,"about_ca_system_score_gemma":0.0003259087,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00106468,"about_ca_topic_score_gemma":0.002103969,"domain_scores_codex":[0.9997066,0.00003760163,0.00002771807,0.00004993117,0.0001027981,0.00007530169],"domain_scores_gemma":[0.9998025,0.00002239148,0.00008433902,0.00001313641,0.00001733246,0.0000602661],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003798852,0.0002051529,0.00007927934,0.00009722386,0.00001588297,0.00003574262,0.00002757033,0.0002344775,0.9963366,0.00006246376,0.00008617969,0.002439641],"study_design_scores_gemma":[0.0002288271,0.005213441,0.00258946,0.00001795841,0.00007506563,0.000202478,0.00006577713,0.002744814,0.9860222,0.00004261228,0.002783324,0.00001382914],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9920152,0.003010064,0.003179741,0.0001714339,0.0001307244,0.00007294751,0.0003391784,0.0002019151,0.0008789366],"genre_scores_gemma":[0.9896818,0.001975397,0.003648983,0.0001602284,0.00004168342,0.0001058946,0.0005761759,0.00003068078,0.003779227],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001377607,"threshold_uncertainty_score":0.004608572,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.005460169342928822,"score_gpt":0.2055581469154827,"score_spread":0.2000979775725539,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}