{"id":"W4409279685","doi":"10.1080/07391102.2025.2487196","title":"Cross-variant immune shield: computational multiepitope vaccine design against B.617.2 to Omicron sub-lineages in SARS-CoV-2","year":2025,"lang":"en","type":"article","venue":"Journal of Biomolecular Structure and Dynamics","topic":"SARS-CoV-2 and COVID-19 Research","field":"Medicine","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Canadian Institutes of Health Research - Antimicrobial Resistance Research Initiative","keywords":"Virology; Biology; Immune system; Microbiology; Genetics","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004848609,0.0002392759,0.0005494758,0.0007632081,0.00008392122,0.0001316012,0.0002192987,0.0002211676,0.000001540028],"category_scores_gemma":[0.0002465602,0.0001957267,0.0001506206,0.0006594858,0.0000662025,0.0001104545,0.0001148772,0.0005387149,0.000001445667],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002178763,"about_ca_system_score_gemma":0.0004379942,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00007429336,"about_ca_topic_score_gemma":0.00007756962,"domain_scores_codex":[0.9982,0.0001024568,0.0007325381,0.000275803,0.0003735424,0.0003156328],"domain_scores_gemma":[0.9990379,0.0001293292,0.0001908208,0.0002246169,0.0003614703,0.0000558464],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001684548,0.0001217306,0.01432279,0.0001302364,0.0002122863,0.001533898,0.0002201316,0.000923645,0.9659205,0.0002702797,0.0001068405,0.01455311],"study_design_scores_gemma":[0.009827886,0.0009593118,0.08128978,0.0006211672,0.0001538954,0.001148447,0.0001460919,0.08248322,0.8182093,0.002735317,0.001993282,0.0004323207],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8532341,0.001268226,0.14386,0.001016086,0.0002244445,0.000312064,0.00001894772,0.000009957103,0.00005621342],"genre_scores_gemma":[0.9729351,0.00003448237,0.01115134,0.01573814,0.00009373882,0.000002205038,0.00001129942,0.00002360099,0.00001004676],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1477112,"threshold_uncertainty_score":0.7981501,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01374664684791451,"score_gpt":0.335976656273288,"score_spread":0.3222300094253735,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}