{"id":"W4409280604","doi":"10.1016/j.biopsych.2025.02.311","title":"74. Genome-Wide Significance Reconsidered: Low-Frequency Variants and Regulatory Networks in Autism","year":2025,"lang":"en","type":"article","venue":"Biological Psychiatry","topic":"Autism Spectrum Disorder Research","field":"Neuroscience","cited_by":0,"is_retracted":false,"has_abstract":false,"ca_institutions":"Hospital for Sick Children; University of Toronto","funders":"","keywords":"Autism; Biology; Genome; Genetics; Computational biology; Psychology; Neuroscience; Developmental psychology; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.01336886,0.0006427994,0.0008287186,0.001561134,0.001901657,0.002562258,0.002304257,0.00407674,0.004585451],"category_scores_gemma":[0.03273591,0.0003371641,0.001478311,0.002015416,0.004965292,0.0024415,0.001219425,0.004764579,0.0006353814],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000653966,"about_ca_system_score_gemma":0.001375315,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.01097251,"about_ca_topic_score_gemma":0.01831412,"domain_scores_codex":[0.9941655,0.002449972,0.0003552155,0.001879235,0.0006615786,0.0004884971],"domain_scores_gemma":[0.9759262,0.0195106,0.0007615107,0.001633111,0.001248137,0.0009203798],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"observational","study_design_scores_codex":[0.001849926,0.0001374706,0.2835844,0.001030147,0.005191884,0.004444125,0.004158065,0.004300805,0.01896306,0.1356159,0.1251567,0.4155675],"study_design_scores_gemma":[0.0005373662,0.0004418905,0.5087582,0.001510152,0.005728182,0.005255891,0.002495926,0.007302064,0.005379566,0.3609871,0.1012396,0.0003640575],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"commentary","genre_gemma":"empirical","genre_scores_codex":[0.2494204,0.06560328,0.05826035,0.562066,0.01480143,0.00009106036,0.00464341,0.0008153904,0.04429872],"genre_scores_gemma":[0.9069613,0.006151695,0.008706636,0.063571,0.01059995,0.00006320707,0.0004863466,0.0002133353,0.003246675],"genre_candidate":"empirical","genre_consensus":null,"teacher_disagreement_score":0.01336886,"threshold_uncertainty_score":0.07070214,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02936066003237443,"score_gpt":0.2830422439211142,"score_spread":0.2536815838887397,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}