{"id":"W4409280629","doi":"10.1016/j.biopsych.2025.02.400","title":"163. Dose Prediction of α5-GABA Receptor Modulation From Simulated EEG of Depression Severity","year":2025,"lang":"en","type":"article","venue":"Biological Psychiatry","topic":"Neuroscience and Neuropharmacology Research","field":"Neuroscience","cited_by":0,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Toronto; Centre for Addiction and Mental Health","funders":"","keywords":"Depression (economics); Modulation (music); Electroencephalography; Neuroscience; GABAA receptor; Receptor; Psychology; Internal medicine; Medicine; Physics; Economics; Acoustics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001645828,0.0002427322,0.0001242609,0.0001176585,0.00007317231,0.0001746829,0.0001354995,0.0005166417,0.002482926],"category_scores_gemma":[0.001735967,0.00007811066,0.0003216272,0.00007962698,0.00008556465,0.00008509376,0.00009635853,0.0002042933,0.0004748674],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001462178,"about_ca_system_score_gemma":0.0001278806,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002788653,"about_ca_topic_score_gemma":0.002340867,"domain_scores_codex":[0.99994,0.00001678108,0.000004366803,0.00001369249,0.00001579514,0.000009220636],"domain_scores_gemma":[0.9997414,0.0001874795,0.00001334959,0.00001623397,0.00002713894,0.00001437238],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"simulation_or_modeling","study_design_scores_codex":[0.01660168,0.0009765516,0.1317605,0.000530237,0.0004822796,0.001153965,0.0003347286,0.2330648,0.4892314,0.001772717,0.005711283,0.1183798],"study_design_scores_gemma":[0.0003804493,0.002980316,0.4132357,0.00006808582,0.0001885586,0.00115774,0.0001213925,0.4966012,0.08281646,0.00110858,0.001270926,0.00007070002],"study_design_candidate":"simulation_or_modeling","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9753401,0.00009244193,0.01757331,0.0001140815,0.00008581387,0.00007972351,0.001657674,0.0003351093,0.004721751],"genre_scores_gemma":[0.9985223,0.00001380418,0.0008936753,0.00001820823,0.000002449908,0.00001357108,0.0002114835,0.00001142095,0.0003130515],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002788653,"threshold_uncertainty_score":0.008306205,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.06233172094740725,"score_gpt":0.3521849222814982,"score_spread":0.2898532013340909,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}