{"id":"W4409281255","doi":"10.1016/j.biopsych.2025.02.605","title":"367. Inspire 7: Intellectual Disability Polygenic Risk Evaluation in 7q11.23 Deletion Syndrome","year":2025,"lang":"en","type":"article","venue":"Biological Psychiatry","topic":"Williams Syndrome Research","field":"Neuroscience","cited_by":0,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Toronto; Hospital for Sick Children","funders":"","keywords":"Polygenic risk score; Intellectual disability; Medicine; Psychology; Genetics; Neuroscience; Biology; Psychiatry; Gene; Genotype","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0009781044,0.0006028984,0.0003884011,0.001129772,0.0006030957,0.0006814506,0.0006118994,0.001426156,0.04176756],"category_scores_gemma":[0.003922788,0.0002065904,0.0003440247,0.0003163331,0.0001989671,0.0003183739,0.000938163,0.0005135922,0.01104344],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005989074,"about_ca_system_score_gemma":0.0008924029,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002390714,"about_ca_topic_score_gemma":0.005899259,"domain_scores_codex":[0.9995857,0.0001017042,0.0000357717,0.00005401114,0.0001678326,0.00005508529],"domain_scores_gemma":[0.9990016,0.000475661,0.00006441352,0.00006952001,0.000164191,0.0002246182],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"not_applicable","study_design_gemma":"observational","study_design_scores_codex":[0.002831767,0.000461527,0.04991608,0.0003878229,0.0001152439,0.01414103,0.0003241059,0.001544341,0.01213863,0.00406865,0.5291731,0.3848977],"study_design_scores_gemma":[0.003257931,0.002418428,0.1974315,0.001392529,0.0003804041,0.05453905,0.0004459078,0.01491103,0.04910952,0.01764431,0.6581635,0.0003059435],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"other","genre_gemma":"empirical","genre_scores_codex":[0.3321966,0.009824549,0.05684153,0.06765758,0.0095996,0.00297079,0.1182803,0.0381508,0.3644783],"genre_scores_gemma":[0.6662336,0.005313505,0.09644818,0.01361929,0.005777748,0.001751653,0.08338003,0.005057648,0.1224184],"genre_candidate":"empirical","genre_consensus":null,"teacher_disagreement_score":0.04176756,"threshold_uncertainty_score":0.1397265,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.06449246128846196,"score_gpt":0.3521773995607703,"score_spread":0.2876849382723083,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}