{"id":"W4409281338","doi":"10.1016/j.biopsych.2025.02.431","title":"194. Improving Workplace and Psychosocial Function in Treatment-Resistant Depression: Exploratory Outcomes From an Open-Label Feasibility Trial of Psilocybin-Assisted Psychotherapy","year":2025,"lang":"en","type":"article","venue":"Biological Psychiatry","topic":"Psychedelics and Drug Studies","field":"Psychology","cited_by":0,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Toronto","funders":"","keywords":"Psilocybin; Psychosocial; Open label; Psychotherapist; Depression (economics); Psychology; Clinical psychology; Psychiatry; Medicine; Randomized controlled trial; Hallucinogen; Internal medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001849955,0.0007653473,0.001394865,0.0004109314,0.0007993451,0.0005716136,0.0007344711,0.001947904,0.007276939],"category_scores_gemma":[0.00274066,0.0004585517,0.001702293,0.0003404798,0.0009675813,0.0009181643,0.0004063379,0.002435862,0.001170881],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005273527,"about_ca_system_score_gemma":0.001140391,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002735079,"about_ca_topic_score_gemma":0.004885218,"domain_scores_codex":[0.999051,0.0005694872,0.00009008413,0.00008391793,0.00006615803,0.0001393431],"domain_scores_gemma":[0.998574,0.0007080202,0.0001774049,0.0001566384,0.00009831149,0.0002856737],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"nonrandomized_trial","study_design_scores_codex":[0.8770489,0.05276065,0.00219423,0.000482418,0.0009621093,0.00007579396,0.0001470369,0.0004166189,0.007906997,0.0001275658,0.0009658247,0.05691193],"study_design_scores_gemma":[0.5564879,0.4300492,0.01044639,0.00004761336,0.0004387888,0.00002888756,0.0000753826,0.0003279565,0.001450151,0.0001194204,0.0005048531,0.00002341234],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9919506,0.001116259,0.0005803091,0.000498722,0.0001978566,0.002853531,0.0010703,0.00005214346,0.00168022],"genre_scores_gemma":[0.9898232,0.001308102,0.001876919,0.0007657207,0.0002929771,0.002646352,0.0009664172,0.00001731526,0.002302918],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.007276939,"threshold_uncertainty_score":0.02434385,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1218284867834983,"score_gpt":0.4080836992243221,"score_spread":0.2862552124408238,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}