{"id":"W4409281375","doi":"10.1016/j.biopsych.2025.02.455","title":"218. Uncovering the Spatially Resolved Transcriptomic Gene Profile in the Human Dorsal and Medianraphe Nuclei in Major Depressive Disorder and Anti-Depressant Treatment","year":2025,"lang":"en","type":"article","venue":"Biological Psychiatry","topic":"Health, Environment, Cognitive Aging","field":"Environmental Science","cited_by":0,"is_retracted":false,"has_abstract":false,"ca_institutions":"Douglas Mental Health University Institute","funders":"","keywords":"Dorsum; Depressant; Transcriptome; Major depressive disorder; Neuroscience; Gene; Pharmacology; Biology; Gene expression; Genetics; Anatomy","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004521385,0.0002077309,0.0002124104,0.00004080135,0.0002715122,0.00003482413,0.0002476434,0.0001285496,0.0001227222],"category_scores_gemma":[0.00003111066,0.0001085409,0.00003656082,0.0001845171,0.0004442262,0.0000714176,0.0001299675,0.0002547418,0.000008256379],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00008276961,"about_ca_system_score_gemma":0.00001594766,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001500539,"about_ca_topic_score_gemma":0.004062647,"domain_scores_codex":[0.9982277,0.0003906284,0.0002975,0.0005939142,0.0001324703,0.0003577942],"domain_scores_gemma":[0.9994515,0.0001679829,0.00006364565,0.0002674205,0.000001431835,0.00004802064],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.00004441313,0.0002439557,0.9785078,0.000008947121,0.00001209798,0.000008038101,0.0006102466,0.00004274798,0.009959448,0.0001132305,0.00002946033,0.01041963],"study_design_scores_gemma":[0.001710387,0.0001285105,0.9948592,0.00003200467,0.00001612453,0.000003195152,0.0005144699,0.0001676263,0.0002301711,0.001502413,0.0006963424,0.0001395474],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9930093,0.001563508,0.0001279402,0.002890894,0.0001068242,0.001026772,0.00001979735,0.00001693577,0.001237993],"genre_scores_gemma":[0.9975846,0.0007015344,0.0003688258,0.001122912,0.00002878877,0.0001577361,0.000009552353,0.00000876203,0.00001732292],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01635142,"threshold_uncertainty_score":0.4426167,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0152135602654312,"score_gpt":0.2622111909537105,"score_spread":0.2469976306882793,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}