{"id":"W4409281375","doi":"10.1016/j.biopsych.2025.02.455","title":"218. Uncovering the Spatially Resolved Transcriptomic Gene Profile in the Human Dorsal and Medianraphe Nuclei in Major Depressive Disorder and Anti-Depressant Treatment","year":2025,"lang":"en","type":"article","venue":"Biological Psychiatry","topic":"Health, Environment, Cognitive Aging","field":"Environmental Science","cited_by":0,"is_retracted":false,"has_abstract":false,"ca_institutions":"Douglas Mental Health University Institute","funders":"","keywords":"Dorsum; Depressant; Transcriptome; Major depressive disorder; Neuroscience; Gene; Pharmacology; Biology; Gene expression; Genetics; Anatomy","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00005302262,0.00007162581,0.000117485,0.0002495069,0.0002425744,0.0002526279,0.0001094966,0.0001708053,0.001841408],"category_scores_gemma":[0.0001324079,0.00009236985,0.0001625884,0.000192292,0.0001724266,0.00008683411,0.000131404,0.0001137112,0.0003080827],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001545036,"about_ca_system_score_gemma":0.000188145,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.004410786,"about_ca_topic_score_gemma":0.0115065,"domain_scores_codex":[0.9999703,0.000002430547,0.000001518296,0.00001111889,0.0000058283,0.000008720534],"domain_scores_gemma":[0.9999542,0.000008733352,0.00001081725,0.000003714791,0.0000118819,0.00001061127],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.0007056679,0.00003387264,0.07391924,0.0001090172,0.00004585893,0.000633086,0.0001584156,0.0001420124,0.9030631,0.0004052036,0.0006910667,0.02009346],"study_design_scores_gemma":[0.000020442,0.0001927975,0.9334887,0.00001314695,0.00005490077,0.001247219,0.0003882972,0.0006399979,0.06027922,0.0003329381,0.003333369,0.000008992399],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.992896,0.001164496,0.001798133,0.0002117051,0.00003810181,0.00001575818,0.001709054,0.00002502536,0.002141629],"genre_scores_gemma":[0.9926676,0.0005201382,0.001628304,0.0001629385,0.00001671998,0.00003168232,0.001160836,0.00001369798,0.003798058],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004410786,"threshold_uncertainty_score":0.008770227,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0152135602654312,"score_gpt":0.2622111909537105,"score_spread":0.2469976306882793,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}